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Research focuses on analgesics in children.
The Seto lab is devoted to obtaining a complete understanding of the functions, mechanisms of action, and regulation of histone deacteylases (HDACs), an enzyme that catalyze the removal of acetyl groups from the lysine residues of histones. These enzymes play a pivotal role in the regulation of…
Pediatric Interventional Radiology
shoulder and elbow repair
Dr. Eleftherianos studies host-pathogen interactions using a model insect (Drosophila), a nematode parasite (Heterorhabditis), and its symbiotic insect-pathogenic bacterium (Photorhabdus). Research focuses on which genes the bacteria use to infect and persist in the fly, what immune mechanisms are…
Research includes mechanisms of turnover and toxicity of human pancreatic hormone amylin, which are relevant to type-2 diabetes mellitus. Projects involve unraveling structure and composition of membrane machinery regulating insulin release in ß-cell and elucidating the molecular mechanism of…
Recent projects address metabolism and electrophysiology during hypoxia, ischemia, and heart failure. One project examines how chronic selective activation of hypothalamic oxytocin neurons improves cardiac function and favorably alters indices of cardiac ischemia and damage that occurs in heart…
Research focuses on understanding which processes are essential for latent survival of Mycobacterium tuberculosis, which causes tuberculosis. They achieve this through the development of small molecule chemical tools, which inhibit specific enzymes thought to be important in latency and examine…
Research interests focus on medical and pediatric dermatology, including acne, eczema, psoriasis, skin infections, hair loss, wound healing, urticaria, blistering diseases, lupus, sarcoidosis, and skin cancer.
His research is related to trauma surgery, critical care, and rapid response systems. Research projects include diagnosis and management of coagulation disorders following trauma, delirium in the ICU, and optimal design of rapid response systems.