Professor
Primary Department
Microbiology, Immunology, & Tropical Medicine
Affiliation
School of Medicine and Health Sciences
Research Interests
Research interests include: 1. Molecular biology of the hookworm infective process - the role of nematode insulin signaling in infection 2. Anthelmintic resistance - determining the genetic mechanism underlying hookworm anthelmintic resistance 3. Genetic manipulation of nematodes - transgenesis and CRISPR/Cas9 editing in hookworms and other nematodes 4. Human hookworm challenge model - testing hookworm vaccines in a human challenge model. 5. Helminth therapy - using human hookworms to treat inflammatory and autoimmune diseases
Keywords
hookworms, nematode development, insulin signaling, soil transmitted helminths, anthelmintic resistance, nematode transfection, biogas, cancer immunology & immunotherapy, Infectious Diseases
Research Level
T0 / T1: Basic Science Discovery and Initial Translation to Humans
T2: Translation to Patients
Research Method(s)
- Using hookworms to treat autoimmune diseases, including Crohn's, multiple sclerosis, rheumatoid arthritis and others
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