Ljubica Caldovic, PhD

Professor
Primary Department
Genomics & Precision Medicine
Secondary Department
Pediatrics
Affiliation
Children's National Hospital
Research Interests

Research examines regulation of the urea cycle and ammonia toxicity to the brain. Approaches include transcriptional and proteomic profiling to examine global changes in the liver and brain related to ammonia load, bioinformatics and functional genomics approaches to evaluate pathogenicity of non-coding  sequence variants, and phenotypic screens for drugs that protect CNS from ammonia toxicity.

Keywords

Urea cycle, nitrogen metabolism, functional genomics, drug screening, gene regulation, animal models of hyperammonemia, Biochemistry , Genomics

Research Level
T0 / T1: Basic Science Discovery and Initial Translation to Humans
Research Method(s)
  • Proteomics
  • Bioinformatics
  • RNAseq
  • Tissue culture
  • Reporter gene assays