Professor
Primary Department
Biochemistry & Molecular Medicine
Affiliation
School of Medicine and Health Sciences
Research Interests
The Seto lab is devoted to obtaining a complete understanding of the functions, mechanisms of action, and regulation of histone deacteylases (HDACs), an enzyme that catalyze the removal of acetyl groups from the lysine residues of histones. These enzymes play a pivotal role in the regulation of gene transcription and are indispensable in numerous eukaryotic biological processes involving chromatin. Their research examines the molecular mechanisms by which HDAC inhibitors alter gene expression in both normal and cancer cells.
Keywords
Cancer, Chromatin, Histone Deacetylase Inhibitors, Lymphoma, Mantle-Cell, Histone Deacetylases, Transcription, Genetic, Biochemistry , Cancer
Research Level
T0 / T1: Basic Science Discovery and Initial Translation to Humans
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