Associate Professor
Primary Department
Biological Sciences
Affiliation
Columbian College of Arts & Sciences
Research Interests
Research includes mechanisms of turnover and toxicity of human pancreatic hormone amylin, which are relevant to type-2 diabetes mellitus. Projects involve unraveling structure and composition of membrane machinery regulating insulin release in ß-cell and elucidating the molecular mechanism of aberrant protein (amyloid) formation in the islets of Langerhans.
Keywords
Islet Amyloid Polypeptide, Insulin, Diabetes Mellitus, Type 2, Pancreatic Hormones, Amyloidogenic Proteins, Amyloidosis, Islets of Langerhans,
Research Level
T0 / T1: Basic Science Discovery and Initial Translation to Humans
Research Method(s)
- Biological microimaging
- Atomic force microscopy
- High resolution optical confocal fluorescence microscopy
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