Abstract: Standalone AlphaFold 3 provides a powerful, data-driven approach for modeling protein structures with bound ligands, including glycans. We comprehensively evaluated its performance in modeling glycans by testing chemical structure input formats, benchmarking results with crystal structures, and exploring various glycan classes. To support broader applications, we developed JAAG, a user-friendly web tool that helps researchers generate correct glycan input syntax for AlphaFold 3.
Featured Speakers
Kelley Moremen, MD, Professor, Department of Biochemistry and Molecular Biology, University of Georgia, Athens
Chin Huang, PhD, Candidate & Graduate Research Assistant, University of Georgia, Athens