Non-invasive vascular surgery and microcirculation physiology, particularly with diabetes; effects of homocysteine on endothelial and smooth muscle cell function and vascular disease.
Quality Improvement & Patient Safety, Graduate Medical Education, Transitions of Care, Medication Safety, Medication Reconciliation and Heart Failure Using Propensity Matching Design,
Molecular and epigenetic changes in adipose tissue during the development of metabolic syndrome; associated comorbidities, and peripheral tissue (macrophages and skeletal muscle) dysfunction.
Laryngeal reflex activity in infants and the role of gastroesophageal reflux in causing upper airway pathology, as well as vascular anomaliesl;efficacy of propranolol versus prednisolone in hemangiomas of infancy.
diabetes, macrovascular disease, microvascular disease, cognitive testing, MRI techniques, hypoglycemia, DNA methylation, cancer control and health equity,
The effects of demographic, traditional, and diabetes-related risk factors on the risk of micro- and macrovascular disease in type 1 and 2 diabetes; the extent to which these factors co-progress over time; employing various longitudinal and survival modeling techniques, and assessments of mediation.
Prenatal sonographic and MRI evaluation of congenital anomalies, Transcranial Doppler (TCD) evaluation of neonatal and pediatric cerebrovascular injury, and blunt abdominal trauma.
Nutrition in kidney disease, genetics of hypertension, and glomerular filtration rate (GFR) loss in peritoneal dialysis; nutrition in Chronic Kidney Disease, lifestyle modifications, the gut microbiome, protein energy metabolism, and end stage renal disease (ESRD) prevention.
Non-invasive imaging to assess coronary artery disease treatment strategies, atherosclerotic plaque composition, and their thrombotic complications; new products for some of the world’s leading healthcare companies.
Health, Human Function, & Rehabilitation Sciences:SMHS
medical education, Educational outcomes, Computer-assisted learning, Fall prevention, Aging, Health and fitness, Simulation, Cardiovascular, Pulmonary, Acute Care,
The scholarship of teaching and learning and related outcomes of health profession students; use of information and simulation in facilitating learning, and physical ability and activities in aging people.
Early cardiac detection in cancer survivors, evaluation of pulmonary hypertension with non-invasive cardiac modalities, heart failure and cardiogenetics.
Health disparities, substance abuse, youth violence, sexual risk, obesity prevention, and how poverty and marginalization intesrsect with key health issues such as HIV/AIDs.
Thoracic Surgery (Cardiothoracic Vascular Surgery); Surgery; Clinical Outcomes; Small Cell Lung Cancer; Non-Small Cell Lung Cancer; Lung Cancer; Lung Cancer Screening; Health Equity; Population Health; Health Services; Public Health
Lung and Esophageal Cancer; Mediastinal Masses and Cysts; Benign Foregut Surgery including Hiatal Hernia; Minimally Invasive Surgery including Robotic-Assisted; Clinical Outcomes; Cancer Care Quality; Lung Cancer Screening; Cancer Early Detection; Incidental Lung Nodules; Disparities in Lung Cancer Outcomes and Screening
State-of-the-art engineering methods to examine the electrical and mechanical function of cardiac cells and heart tissue; tools for optical actuation and sensing, imaging, and control to examine normal and abnormal excitation in the heart, including arrhythmias.
Prevention intervention and evaluating intervention programs using communication and marketing strategies;tobacco and cancer control; nutrition, physical activity, and obesity; diabetes; asthma; HIV/STDs; and reproductive health; the use of digital media to deliver and evaluate health interventions.
Nutrition and immunity through a translational research perspective; the role of the microbiome and nutrition in promoting health, and the consequences of malnutrition in obesity; evaluating the role of vitamin D as an immune modulatory hormone.
Expertise in pulmonary hypertension (PH); epidemiology of pulmonary hypertension, imaging the right ventricle, understanding PH associated with left heart disease and chronic thromboembolic disease and the development and evaluation of novel pharmacological therapies for PAH;clinical trials that explore the efficacy and safety of new drugs
Research focuses on the pathogenesis, genetics, and pharmacogenetics of hypertension, including organ to organ communication, e.g., gastrorenal communication.
Metabolism and electrophysiology during hypoxia, ischemia, and heart failure; chronic selective activation of hypothalamic oxytocin neurons improves cardiac function and favorably alters indices of cardiac ischemia and damage that occurs in heart failure.
Sepsis metabolism and how decreased energy production affects innate immunity; identification oftreatment targets that will improve the metabolic profile of septic patients and subsequently alleviate the hyperimmune response that leads to multi-organ dysfunction.
3D modeling of congenital heart disease, and the use of computational fluid dynamics to guide therapy, including the Fontan operation, the arterial switch in Transposition of Great Arteries, and pulmonary valve replacement in repaired Tetralogy of Fallot.
Epidemiology and quantitative policy analysis with the goal of identifying cost-effective and politically feasible policy solutions to promote community health.
Parental influences on children food consumption and obesity development, dietary assessment methodology, food insecurity, and social determinants of health; cancer control and health equity
Next-generation soft, lightweight, and bio-compatible materials and devices with an emphasis on creating inorganic and organic classes of optoelectronic systems.
Inflammatory secondary complications of HIV infection experienced by those living longer with the disease, compared to their aging, uninfected counterparts.
Novel drug for treating sickle cell pain and investigating specific genetic mutations that might be associated with irregular heartbeats in this high-risk population.
Post-traumatic stress disorder as a strong predictor of cardiovascular disease (CVD);multi-disciplinary approaches; integrative (i.e., neuroimmune) mechanisms related to the brain neurocircuitry involved in cardiovascular autonomic and fear/stress regulation.
Genomic testing to assess the population at risk for premature coronary artery disease, and to determine the outcome of patients with congestive heart failure; minimally invasive interventional procedures including trans-radial cardiac catheterization and interventions in women and elderly population.
Cardiovascular disease, genomics, and stem cells; special interest in the diagnosis of coronary artery disease by changes in the RNA transcriptome in whole blood. Using RNA sequencing of whole blood, his team has identified unique patterns with strong predictive ability for coronary artery disease. This RNA biomarker panel is in the process of validation for FDA clearance for a clinical test for CAD in patients presenting with chest pain, or other indications of CAD; RNA biomarkers of appendicitis
Autonomic and respiratory control of cardiovascular function in both normal physiological homeostasis as well as alterations that initiate and/or sustain cardiorespiratory diseases; targets in the autonomic nervous system control of cardiac function that can reduce and/or prevent highly prevalent and devastating cardiovascular diseases, including obstructive sleep apnea (OSA) and heart failure; cellular properties, neuronal network and in-vivo reflex control of pre-motor parasympathetic cardio-inhibitory vagal neurons located in the brainstem that generate parasympathetic activity to the heart.
Long-term care of children after renal transplantation and those with difficult nephrotic syndrome; identifying nutritional vitamin D deficiency and monitoring for bone health; monitoring for cardiovascular health; and monitoring for common viruses including Epstein Barr Virus that can cause a cancer in children after transplantation known as post-transplant lymphoproliferative disorder.
Liver fibrosis associated with biliary atresia; systems biology of obesity surgery, and the safety and effectiveness of various weight loss procedures in adolescents.
Social Media, Weight Loss, Body Image, Exercise, Physical Activity, Obesity, Tobacco Use, Cancer control and health equity, Cancer , Patient-Centered Research
Evidence-based psychosocial interventions for physical activity and weight management through innovative delivery channels, predominantly targeted to young adults;physical activity, weight loss, tobacco use, body image and stress.
health equity health function, Prevention and treatment of cardiovascular disease, Hypertension, Racial & ethnic disparities, Quality improvement, Clinical trials,
Prevention, treatment, and management of hypertension and cardiometabolic disease in special populations, and translating evidence-based methods to curb these disparate effects; role of racial and ethnic disparities in medication adherence; clinical trial methodologies and the application of systematic and scoping review methodologies; large multidisciplinary research teams, and in treating patients with chronic hypertension.
Cardiovascular diseases, heart and lung transplant immunology, ischemia, and angiogenesis and vasculogenesis in the context of wound healing in diabetic patients.
Alterations in muscle energetics in heart failure and diabetes mellitus, role of dietary sodium content in heart failure, and mobile health projects harnessing cell phone technology for the treatment of heart failure and diabetes.
Designing targeted translational therapies and new diagnostic methods; understanding system interactions (i.e. cell-cell and cell-particle) and delivery platforms (particle-based targeting strategies as well as cellular therapeutics).
Management of hypertension,psychosocial issues including quality of life, sleep disorders and pain perception in patients with end-stage renal disease treated with hemodialysis.
Environmental influences on cardiovascular function; how endocrine disrupting chemicals, which are used in the manufacturing of medical devices and consumer products, can alter cardiac electrical and mechanical function.
Aging;modifiable risk factors for cognitive decline, cognitive impairment, dementia, and dementia-related brain changes assessed via neuroimaging in older adults' how environmental pollutants or toxins contribute to accelerated cognitive deterioration in older adults, the complex relationship between lifecourse vascular risk factors and cognitive health, the relative contribution of multiple brain pathologies to cognitive status, and race/ethnic disparities in the incidence and diagnosis of dementia. Dr. Power also has an interest in epidemiologic methods and statistical approaches, particularly causal inference methods.
Cardiovascular disease in patients with chronic kidney disease, optimal blood pressure target for protection of kidney disease and cardiovascular disease, inflammation in chronic kidney disease, and cardiovascular disease, and mechanism of muscle wasting in renal disease;modulating gut microbiome using designer pre-biotics and pro-biotics; Chronic Renal Insufficiency Cohort (CRIC) study ancillary project that explores the genetic basis for progression of renal and cardiovascular diseases. He is also the principal investigator for the Systolic Blood Pressure Interventional Trial (SPRINT)
immune mechanisms that underlie urban minority childhood asthma, with a current focus on obesity-related asthma; the role of epigenetics in establishing the non-atopic immune patterns among obese children with asthma, the mechanisms by which metabolic abnormalities are associated with the non-atopic immune response and the mechanisms that link systemic non-atopic immune responses with airway disease.
School- and community-based intervention studies focused on diverse lower-income children and youth. Primary outcomes of these studies have included improving physical activity and dietary patterns with the ultimate goal of improving health outcomes including obesity prevention, cardiometabolic risk, cognitive health, and well-being.
Comparative public health regulatory institutions and systems as focused on chronic (non-communicable) diseases, food, obesity, environment, psychoactive substances, and health care systems.
Arrhythmias, tissue engineering, and stem cell based cardiovascular repair;v initial stages of ectopic beat formation, uncovered the adverse cardiac effects of plasticizers, anti-arrhythmogenic effects of stem cells grafts and novel ways to visualize necrotic tissue in vivo; new generation of intracardiac visualization catheters, tissue engineered pumps aiding flow of biological fluids, light controlled muscle pumps, and cardiac effect of snake venoms.
Survival and differentiation of human adult stem cells in hyperglycemia. His current research projects include: the effect of exercise, incretins & glucose transport inhibitors and artificial sweeteners on endothelial function and endothelial progenitor cells (EPCs) in patients with Prediabetes and type 2 diabetes. The Sen Lab is also studying use of genetically modified EPCs and mesenchymal stromal cells (MSCs) in mouse models of diabetes complications such as cardiovascular disease, chronic kidney disease and peripheral vascular disease.
Dydrocarbon receptor signaling affects on obesity mediation, life span, cardiac gene expression, and growth, and also studies heparan sulfates in the lung.
Clinical research experience in the area of minimally invasive neurosurgery; treatment of aneurysms, dural arteriovenous fistulae, and brain tumors using the most innovative, least invasive approaches.
Applied biostatistics;HIV, cancer, obesity, mental health, maternal and infant development, chemical and stress-related environmental exposures, and other health issues.
Cardiomyopathy associated with muscular dystrophies; cardiac drug development in the dystrophin deficient mdx mouse model; imaging outcome measures using both echocardiography and MR imaging and serum biomarkers in DMD related cardiomyopathy.
the consumption and health effects of sugar-sweetened beverages and low-calorie (artificial) sweeteners, with an emphasis on their consumption during childhood.
Dietary assessment methods in diverse populations; the role of diet and other lifestyle factors on chronic disease risk in minority populations, and age-related functional declines in older individuals; cardiovascular health with age-related declines in physical and cognitive function, and the study of dietary trajectories over the adult life course and their associations with physical function, disability, and mortality.
Research interests lie primarily in the treatment of benign and malignant tumors of the head and neck, microvascular free tissue transfer, and transoral robotic surgery (TORS) with an emphasis on preserving functional outcomes.
Outcome analysis utilizing cardiac imaging for identifying prognostic risk factors in cardiac surgery; AIDS-related thoracic and cardiac disease; cardiovascular disease in sleep apnea and right heart dysfunction; donor heart and lung preservation; imaging and revascularization for LV dysfunction (heart failure), valvular heart surgery; off-bypass (OPCAB) coronary operations; cancer and tumor markers (DNA pooling) in esophageal and lung cancer.
Molecular and cellular mechanisms, especially those related to renal sodium transport, involved in salt-sensitive hypertension and aldosterone escape; the role of mitochondrial function in renal epithelial cells following anoxic injury.
Epidemiology and prevention intervention on risky health behaviors and health problems, including substance use, especially tobacco smoking, obesity, risky sexual behaviors, unintentional injuries, mental health disorders, and medical problems, e.g. lung cancer and HIV infection. 2) Statistical methodology and causal inference
Role of hypomagnesemia and magnesium deficiency in cardiovascular (CV) inflammation in animal models; antioxidant properties of cardiovascular drugs, effects of elevated cardiac iron levels in rodents, and iron accumulation and oxidative injury in endothelial cells.
Central nervous system mechanisms that contribute to the development of cardiovascular (e.g., hypertension) and metabolic (e.g., obesity) disorders, with an emphasis on endoplasmic reticulum stress, alterations in reactive oxygen species, and transcription factor activation.