Professor
Primary Department
Biochemistry & Molecular Medicine
Secondary Department
GW Cancer Center
Affiliation
School of Medicine and Health Sciences
Research Interests
Dr. Zhu's research investigates mechanisms of how cells maintain stability of their genome and utilizes this information to identify new drugs for cancer treatment. Projects include: (1) Investigating the mechanisms of how cells response to DNA damage and repair damaged DNA; (2) Identifying new compounds targeting DNA replication apparatus and investigate mechanisms of anti-cancer drug resistance; (3) Investigating how cells prevent DNA re-replication in both normal and cancer cells; and (4) Identifying small molecules that selectively kill cancer cells by inducing DNA re-replication via HTS.
Keywords
Cancer, DNA Replication, Genomic Instability, DNA Repair, DNA Damage, Ovarian Neoplasms, Drug Resistance, Biochemistry , Cancer
Research Level
T0 / T1: Basic Science Discovery and Initial Translation to Humans
Research Method(s)
- High throughput screening assays
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