The main research focus in his lab is to understand the physiological and patho-physiological functions of epigenetic regulators in human health and disease. One major objective is to elucidate the molecular mechanism by which SRC-3 regulates the activity of cancer stem cells. SRC-3 is the second most overexpressed oncogene that plays a significant role in breast cancer. A second objective is to establish the importance of the SRC-3/CSC pathway in the therapy resistance and to validate the SRC-3/CSC pathway as a potential therapeutic target for aggressive and therapy resistant breast cancer. Another research focus is the biological function of the chromatin remodeling protein ARID4B. In collaboration with Dr. Mei-Yi Wu, his lab is investigating the biological function of ARID4B using novel knockout and knockin mouse models, in order to elucidate the molecular mechanism underlying its function using proteomics, genomics and biochemical approaches.
Cancer, Nuclear Receptor Coactivator 3, Cell Transformation, Neoplastic, Carcinogenesis, Breast Neoplasms, Antineoplastic Agents, Co-Repressor Proteins, Biochemistry , Cancer