Goberdhan Dimiri, PhD

The major focus of my laboratory is to define the molecular mechanisms of cellular senescence, cell immortalization and oncogenesis in human cells. We are particularly interested in determining the role of a family of proteins that act as epigenetic gene silencers known as Polycomb Group (PcG) proteins in regulation of these processes. Cells must overcome senescence in order to further undergo genetic and phenotypic changes to become cancerous.