Professor Emilia Entcheva directs the Cardiac Optogenetics and Optical Imaging Laboratory. Her research group combines biophotonics tools with human stem-cell-derived cardiomyocyte technology and gene editing approaches to aid the advancement of personalized medicine. The lab played a key role in bringing optogenetics to the cardiac field and validating its use experimentally and computationally. The lab combines cell and tissue engineering, genetic engineering, all-optical cardiac electrophysiology, instrumentation and control, machine learning and transcriptomics analysis to help improve the maturity of engineered human heart tissues and their use in high-throughput drug-screening applications. Professor Entcheva is an AIMBE Fellow and her work is supported by the NSF, NIH, AHA, HFSP and others.
Heart, Arrhythmias, Cardiac, Optogenetics, Drug Testing, Genetic Therapy, Cancer Engineering
- Optical mapping
- Optogenetics
- High-throughput all-optical electrophysiology
- Stem-cell-derived cardiomyocytes
- Genetic engineering
- Computational modeling