SEH 2000
School of Engineering & Applied Science
800 22nd Street, NW Washington, DC
Abstract
Many questions at the forefront of biology depend on the interactions of millions of single cells. My lab develops technologies for studying large numbers of single cells. In this talk, I will describe our approaches for sorting cells based on genomic and transcriptomic markers, and performing multi-omics analysis of single cells that allow simultaneous characterization of genomic, transcriptomic, and proteomic signatures. I will also describe how we are adapting these techniques to integrate genomics with other single cell measurement approaches, including imaging, mass spectrometry, and atomic force microscopy. Finally, I will describe how we are using these techniques to build cells into controlled consortia for microbiological studies and bottom-up tissue synthesis.
Featuring
Dr. Adam Abate
Introducing Adam R. Abate, he received an AB in Physics from Harvard College in 2002, a Masters in Physics from UCLA in 2004, and a PhD in Physics from the University of Pennsylvania in 2006. He returned to Harvard for a postdoc in Physics in the lab of David Weitz, working on a variety of topics in soft matter physics, chemical and microparticle synthesis, and microfluidics. While a postdoc, he developed a droplet-based microfluidic sequencer that became the foundation for the sequencing company GnuBIO.
He has founded several additional companies, including Mission Bio, Fluent Bio, and Scribe Biosciences. He is a Professor at the University of California, San Francisco in the Department of Bioengineering and Therapeutic Sciences and an Investigator in QB3. His research interests are in microfluidics, single cell analysis, and genomics.