Translational Research

The  GW Dermatology Translational Research Program consists of a multidisciplinary, collaborative group of investigators from numerous departments, divisions, and institutions. The overall goal of this program is to create a collaborative network that will facilitate continued discoveries, enhancing our understanding of skin pathology and cutaneous disease states and translating this knowledge into innovative diagnostics and therapies.

The program in its current form consists of an ongoing collaboration between:

  • The Department of Dermatology at the George Washington School of Medicine and Health Sciences

These collaborations are focused on investigating polymeric and paramagnetic  nanotechnologies which allow for controlled and sustained delivery of a wide spectrum of physiologically and medicinally relevant molecules ranging from nitric oxide, melanin, siRNA, curcumin peptides and large proteins, to well established diagnostic agents and therapeutics suitable for chemotherapy and MRI imaging. This technology has yielded materials that can be delivered topically, subcutaneously, and intravenously.

Examples of several recent publications

Kao S, Kiss A, Efimova T, Friedman A. An ex-vivo evaluation of cytotoxicity and melanocyte viability after A-101 hydrogen peroxide topical solution 40% or cryosurgery treatment in Seborrheic Keratosis lesions. J Am Acad Dermatol. 2018 Mar 27. pii: S0190-9622(30488-2. doi:10.1016/j.jaad.2018.03.034. [Epub ahead of print]

Costa-Orlandi CB, Mordorski B, Baltazar LM, Mendes-Giannini MJS, Friedman JM, Nosanchuk JD, Friedman AJ. Nitric Oxide Releasing Nanoparticles as a Strategy to Improve Current Onychomycosis Treatments. J Drugs Dermatol. 2018; 17(7):717-720.

Qureshi A, Abate L, Yosipovitch P, Friedman A. A Systematic Review of Evidence-Based Treatments for Prurigo Nodularis. J Am Acad Dermatol https://doi.org/10.1016/j.jaad.2018.09.020

Krausz AE, Adler BL, Makdisi J, Schairer D, Rosen J, Landriscina A, Navati M, Alfieri A, Friedman JM, Nosanchuk JD, Rodriguez-Gabin A, Ye KQ, McDaid HM, Friedman AJ. Nanoparticle-Encapsulated Doxorubic in Demonstrates Superior Tumor Cell Kill in Triple-Negative Breast Cancer Subtypes Intrinsically Resistant to Doxorubicin. Prec. Nanomed. 2018;1(3):172-185.

Marks DH, Qureshi A, Friedman A. Evaluation of Prevention Interventions for Taxane-Induced Dermatologic Adverse Events: A Systematic Review. JAMA Dermatol. Published online October 31, 2018. doi:10.1001/jamadermatol.2018.3465.

Krausz AE, Adler BL, Cabral V, Navati MH, Doemer J, Charafeddine R, Chandra D, Liang H, Gunther L, Clendaniel A, Harper S, Friedman JM, Nosanchuk JD, Friedman AJ. Curcumi- encapsulated nanoparticles as an innovative antimicrobial and wound healing agent. Nanomedicine. 2014 Sep 16. pii: S1549-9634(14)00527-9. doi: 10.1016/j.nano.2014.09.004. [Epub ahead of print].

Charafeddine RA, Makdisi J, Schairer D, O'Rourke BP, Diaz-Valencia JD, Chouake J, Kutner A, Krausz A, Adler B, Nacharaju P, Liang H, Mukherjee S, Friedman JM, Friedman A, Nosanchuk JD, Sharp DJ. Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing.  J Invest Dermatol. 2015 Mar 10. doi: 10.1038/jid.2015.94. [Epub ahead of print]

Baltazar LM, Karusz AE, Souza AC, Adler B, Landriscina A, Musaev T, Nosanchuk JD, Friedman AJ. Trichophyton rubrum is inhibited by free and nanoparticle encapsulated curcumin by induction of nitrosative stress after photodynamic activation. PLoS ONE 10(3): e0120179. doi:10.1371/journal. pone.0120179

Rosen J, Landriscina A, Adler B, Krausz A,Doerner J, Navati M, Gravekamp C, Nosanchuk J, Friedman A. Characterization and Assessment of Nanoencapsulated Sanguinarine Chloride as a Potential Treatment for Melanoma. J Drugs Dermatol. 2015;14(5):453-458.

Landriscina A, Musaev T, Rosen J, Ray A, Nacharaju P, Nosanchuk JD, Friedman AJ. N-acetylcysteine S-nitrosothiol Nanoparticles Prevent Wound Expansion and Accelerate Wound Closure in a Murine Burn Model. J Drugs Dermatol. 2015. 4(7):726-732.

Landriscina A, Rosen J, Blecher-Paz K, Long L, Ghannoum M, Nosanchuk J, Friedman AJ. Nitric oxide-releasing nanoparticles as a treatment for cutaneous dermatophyte infections. Sci Lett 2015, 4: 193

Qin M, Landriscina A, Rosen J, Wei G, Kao S, Olcott W, Agak GW, Paz KB, Bonventre J, Clendaniel A, Harper S, Adler B, Krausz A, Friedman J, Nosanchuk J, Kim J, Friedman AJ. Nitric Oxide Releasing Nanoparticles Prevent Propionibacterium acnes Induced Inflammation by both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune Response. J Invest Dermatol. 2015 Jul 14.