View publications by year:
- 2019
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Sudden Heart Rate Reduction Upon Optogenetic Release of Acetylcholine From Cardiac Parasympathetic Neurons in Perfused Hearts.
Moreno A, Endicott K, Skancke M, Dwyer MK, Brennan J, Efimov IR, Trachiotis G, Mendelowitz D, Kay MW.
Front Physiol. 2019 Jan 28;10:16. doi: 10.3389/fphys.2019.00016. eCollection 2019. PMID: 30745877 - 2018
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Silencing of Hypoglossal Motoneurons Leads to Sleep Disordered Breathing in Lean Mice.
Fleury Curado TA, Pho H, Dergacheva O, Berger S, Lee R, Freire C, Asherov A, Sennes LU, Mendelowitz D, Schwartz AR, Polotsky VY.
Front Physiol. 2019 Jan 28;10:16. doi: 10.3389/fphys.2019.00016. eCollection 2019. PMID: 30745877Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity.
Berger S, Pho H, Fleury-Curado T, Bevans-Fonti S, Younas H, Shin MK, Jun JC, Anokye-Danso F, Ahima RS, Enquist LW, Mendelowitz D, Schwartz AR, Polotsky VY.
Am J Respir Crit Care Med. 2019 Mar 15;199(6):773-783. doi: 10.1164/rccm.201805-0879OC. PMID: 30309268Combined hypoxia and hypercapnia, but not hypoxia alone, suppresses neurotransmission from orexin to hypothalamic paraventricular spinally-projecting neurons in weanling rats.
Dergacheva O, Mendelowitz D.
Brain Res. 2018 Jan 15;1679:33-38. doi: 10.1016/j.brainres.2017.11.015. Epub 2017 Nov 21. PMID: 29162453 - 2017
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Benefits of oxytocin administration in obstructive sleep apnea.
Jain V, Marbach J, Kimbro S, Andrade DC, Jain A, Capozzi E, Mele K, Del Rio R, Kay MW, Mendelowitz D.
Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L825-L833. doi: 10.1152/ajplung.00206.2017. Epub 2017 Aug 10. PMID: 28798255Altered neurobiological function of brainstem hypoglossal neurons in DiGeorge/22q11.2 Deletion Syndrome.
Wang X, Bryan C, LaMantia AS, Mendelowitz D.
Neuroscience. 2017 Jul 4. pii: S0306-4522(17)30462-1. doi: 10.1016/j.neuroscience.2017.06.057. [Epub ahead of print] PMID:28687307Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure.
Garrott K, Dyavanapalli J, Cauley E, Kate Dwyer M, Kuzmiak-Glancy S, Wang X, Mendelowitz D, Kay M.
Cardiovasc Res. 2017 May 2. doi: 10.1093/cvr/cvx084. [Epub ahead of print] PMID: 28472396Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency.
Fleury Curado T, Fishbein K, Pho H, Brennick M, Dergacheva O, Sennes LU, Pham LV, Ladenheim EE, Spencer R, Mendelowitz D, Schwartz AR, Polotsky VY.
Sci Rep. 2017 Mar 10;7:44392. doi: 10.1038/srep44392. PMID: 28281681Optogenetic identification of hypothalamic orexin neuron projections to paraventricular spinally projecting neurons.
Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D.
Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H808-H817. doi: 10.1152/ajpheart.00572.2016. Epub 2017 Feb 3. PMID: 28159808 - 2016
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Direct projections from hypothalamic orexin neurons to brainstem cardiac vagal neurons.
Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D.
Neuroscience. 2016 Dec 17;339:47-53. doi: 10.1016/j.neuroscience.2016.09.038. Epub 2016 Sep 28. PMID: 27693474How Does Angiotensin Activate Hypothalamic Neurons Essential for Controlling Sympathetic Activity and Blood Pressure?
Mendelowitz D.
Hypertension. 2016 Dec;68(6):1340-1341. Epub 2016 Oct 3. No abstract available. PMID: 27698058Hypoxia and hypercapnia inhibit hypothalamic orexin neurons in rats.
Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D.
J Neurophysiol. 2016 Nov 1;116(5):2250-2259. doi: 10.1152/jn.00196.2016. Epub 2016 Aug 24. PMID: 27559138Oxytocin neuron activation prevents hypertension that occurs with chronic intermittent hypoxia/hypercapnia in rats.
Jameson H, Bateman R, Byrne P, Dyavanapalli J, Wang X, Jain V, Mendelowitz D.
Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1549-57. doi: 10.1152/ajpheart.00808.2015. Epub 2016 Mar 25. PMID: 27016581Parasympathetic Vagal Control of Cardiac Function.
Dyavanapalli J, Dergacheva O, Wang X, Mendelowitz D.
Curr Hypertens Rep. 2016 Mar;18(3):22. doi: 10.1007/s11906-016-0630-0. Review. PMID: 26849575Hard to swallow: Developmental biological insights into pediatric dysphagia.
LaMantia AS, Moody SA, Maynard TM, Karpinski BA, Zohn IE, Mendelowitz D, Lee NH, Popratiloff A.
Dev Biol. 2016 Jan 15;409(2):329-42. doi: 10.1016/j.ydbio.2015.09.024. Epub 2015 Nov 7. Review. PMID: 26554723 - 2015
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Neurotransmission to parasympathetic cardiac vagal neurons in the brain stem is altered with left ventricular hypertrophy-induced heart failure.
Cauley E, Wang X, Dyavanapalli J, Sun K, Garrott K, Kuzmiak-Glancy S, Kay MW, Mendelowitz D.
Am J Physiol Heart Circ Physiol. 2015 Oct;309(8):H1281-7. doi: 10.1152/ajpheart.00445.2015. Epub 2015 Sep 14. PMID: 26371169Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function.
Wengrowski AM, Wang X, Tapa S, Posnack NG, Mendelowitz D, Kay MW.
Cardiovasc Res. 2015 Feb 1;105(2):143-50. doi: 10.1093/cvr/cvu258. Epub 2014 Dec 16. PMID: 25514932 - 2014
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Visualization of oxytocin release that mediates paired pulse facilitation in hypothalamic pathways to brainstem autonomic neurons.
Piñol RA, Jameson H, Popratiloff A, Lee NH, Mendelowitz D.
PLoS One. 2014 Nov 7;9(11):e112138. doi: 10.1371/journal.pone.0112138. eCollection 2014. PMID: 25379676Function and modulation of premotor brainstem parasympathetic cardiac neurons that control heart rate by hypoxia-, sleep-, and sleep-related diseases including obstructive sleep apnea.
Dergacheva O, Weigand LA, Dyavanapalli J, Mares J, Wang X, Mendelowitz D.
Prog Brain Res. 2014;212:39-58. doi: 10.1016/B978-0-444-63488-7.00003-3. Review. PMID: 25194192Chronic intermittent hypoxia and hypercapnia inhibit the hypothalamic paraventricular nucleus neurotransmission to parasympathetic cardiac neurons in the brain stem.
Dergacheva O, Dyavanapalli J, Piñol RA, Mendelowitz D.
Hypertension. 2014 Sep;64(3):597-603. doi: 10.1161/HYPERTENSIONAHA.114.03603. Epub 2014 Jun 23. PMID: 24958501Dexmedetomidine decreases inhibitory but not excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus.
Sharp DB, Wang X, Mendelowitz D.
Brain Res. 2014 Jul 29;1574:1-5. doi: 10.1016/j.brainres.2014.06.010. Epub 2014 Jun 13. PMID: 24933328Chronic intermittent hypoxia-hypercapnia blunts heart rate responses and alters neurotransmission to cardiac vagal neurons.
Dyavanapalli J, Jameson H, Dergacheva O, Jain V, Alhusayyen M, Mendelowitz D.
J Physiol. 2014 Jul 1;592(13):2799-811. doi: 10.1113/jphysiol.2014.273482. Epub 2014 May 16. PMID: 24835174Optogenetic stimulation of locus ceruleus neurons augments inhibitory transmission to parasympathetic cardiac vagal neurons via activation of brainstem α1 and β1 receptors.
Wang X, Piñol RA, Byrne P, Mendelowitz D.
J Neurosci. 2014 Apr 30;34(18):6182-9. doi: 10.1523/JNEUROSCI.5093-13.2014. PMID: 24790189Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability.
Wan R, Weigand LA, Bateman R, Griffioen K, Mendelowitz D, Mattson MP.
J Neurochem. 2014 May;129(4):573-80. doi: 10.1111/jnc.12656. Epub 2014 Feb 10. PMID: 24475741C1 Neurons in the RVLM: are they catecholaminergic in name only? (Commentary on Abbott et al.).
Mendelowitz D.
Eur J Neurosci. 2014 Jan;39(1):97. doi: 10.1111/ejn.12454. No abstract available. PMID: 24387592 - 2013
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Postnatal sulfur dioxide exposure reversibly alters parasympathetic regulation of heart rate.
Woerman AL, Mendelowitz D.
Hypertension. 2013 Aug;62(2):274-80. doi: 10.1161/HYPERTENSIONAHA.113.01552. Epub 2013 Jun 17. PMID: 23774227Developmental changes in GABAergic neurotransmission to presympathetic and cardiac parasympathetic neurons in the brainstem.
Dergacheva O, Boychuk CR, Mendelowitz D.
J Neurophysiol. 2013 Aug;110(3):672-9. doi: 10.1152/jn.01054.2012. Epub 2013 May 8. PMID: 23657280Perinatal sulfur dioxide exposure alters brainstem parasympathetic control of heart rate.
Woerman AL, Mendelowitz D.
Cardiovasc Res. 2013 Jul 1;99(1):16-23. doi: 10.1093/cvr/cvt057. Epub 2013 Mar 14. PMID: 23504550 - 2012
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Modulation of bulbospinal rostral ventral lateral medulla neurons by hypoxia/hypercapnia but not medullary respiratory activity.
Boychuk CR, Woerman AL, Mendelowitz D.
Hypertension. 2012 Dec;60(6):1491-7. doi: 10.1161/HYPERTENSIONAHA.112.197954. Epub 2012 Oct 29. PMID: 23108653Optogenetic approaches to characterize the long-range synaptic pathways from the hypothalamus to brain stem autonomic nuclei.
Piñol RA, Bateman R, Mendelowitz D.
J Neurosci Methods. 2012 Sep 30;210(2):238-46. doi: 10.1016/j.jneumeth.2012.07.022. Epub 2012 Aug 7. PMID: 22890236Synaptic and intrinsic activation of GABAergic neurons in the cardiorespiratory brainstem network.
Frank JG, Mendelowitz D.
PLoS One. 2012;7(5):e36459. doi: 10.1371/journal.pone.0036459. Epub 2012 May 3. PMID: 22570717 - 2011
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Anaesthetics differentially modulate the trigeminocardiac reflex excitatory synaptic pathway in the brainstem.
Wang X, Gorini C, Sharp D, Bateman R, Mendelowitz D.
J Physiol. 2011 Nov 15;589(Pt 22):5431-42. doi: 10.1113/jphysiol.2011.215392. Epub 2011 Sep 19. PMID: 219306025HT1A receptors inhibit glutamate inputs to cardiac vagal neurons post-hypoxia/hypercapnia.
Dergacheva O, Kamendi HW, Wang X, Mendelowitz D.
Respir Physiol Neurobiol. 2011 Dec 15;179(2-3):254-8. doi: 10.1016/j.resp.2011.09.005. Epub 2011 Sep 14. PMID: 21930251GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons.
Griffioen KJ, Wan R, Okun E, Wang X, Lovett-Barr MR, Li Y, Mughal MR, Mendelowitz D, Mattson MP.
Cardiovasc Res. 2011 Jan 1;89(1):72-8. doi: 10.1093/cvr/cvq271. Epub 2010 Aug 24. PMID: 20736238 - 2010
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Clonidine, an alpha2-receptor agonist, diminishes GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus.
Philbin KE, Bateman RJ, Mendelowitz D.
Brain Res. 2010 Aug 6;1347:65-70. doi: 10.1016/j.brainres.2010.06.001. Epub 2010 Jun 8. PMID: 2055387The lateral paragigantocellular nucleus modulates parasympathetic cardiac neurons: a mechanism for rapid eye movement sleep-dependent changes in heart rate.
Dergacheva O, Wang X, Lovett-Barr MR, Jameson H, Mendelowitz D.
J Neurophysiol. 2010 Aug;104(2):685-94. doi: 10.1152/jn.00228.2010. Epub 2010 May 19. PMID:20484535Respiratory modulation of premotor cardiac vagal neurons in the brainstem.
Dergacheva O, Griffioen KJ, Neff RA, Mendelowitz D.
Respir Physiol Neurobiol. 2010 Nov 30;174(1-2):102-10. doi: 10.1016/j.resp.2010.05.005. Epub 2010 May 7. Review. PMID: 20452467