Publications

        View full listing of publications by this faculty member.

  • Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams A, Pflugfelder SC, de Paiva CS. Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice.Exp Eye Res. 2018 Apr;169:91-98. doi: 10.1016/j.exer.2018.01.024. Epub 2018 Jan 31.PMID: 29407221, PMCID: PMC: 29407221
  • Kaplan N, Ventrella R, Peng H, Pal-Ghosh S, Arvanitis C, Rappoport JZ, Mitchell BJ, Stepp MA, Lavker RM, Getsios S. EphA2/Ephrin-A1 Mediate Corneal Epithelial Cell Compartmentalization via ADAM10 Regulation of EGFR Signaling. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):393-406. doi: 10.1167/iovs.17-22941.PMID: 2935135, PMCID: PMC: 2935135
  • Gjika E, Pal-Ghosh S, Tang A, Kirschner M, Tadvalkar G, Canady J, Stepp MA, Keidar M. Adaptation of Operational Parameters of Cold Atmospheric Plasma for in Vitro Treatment of Cancer Cells. ACS Appl Mater Interfaces. 2018 Mar 21;10(11):9269-9279. doi: 10.1021/acsami.7b18653. Epub 2018 Mar 6.PMID: 29473408, PMCID: PMC: 29473408
  • Pal-Ghosh S, Tadvalkar G, Stepp MA. Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):4959-4975. doi: 10.1167/iovs.17-21531.PMID:2897336, PMCID:PMC2897336
  • Stepp MA, Tadvalkar G, Hakh R, Pal-Ghosh S. Corneal epithelial cells function as surrogate Schwann cells for their sensory nerves. Glia. 2017; 65(6):851-863. NIHMSID: NIHMS828394 PubMed [journal] PMID: 27878997, PMCID: PMC5395310
  • Pal-Ghosh S, Pajoohesh-Ganji A, Tadvalkar G, Kyne BM, Guo X, Zieske JD, Stepp MA. Topical Mitomycin-C enhances subbasal nerve regeneration and reduces erosion frequency in the debridement wounded mouse cornea. Experimental eye research. 2016; 146:361-9. NIHMSID: NIHMS730540 PubMed [journal] PMID: 26332224, PMCID:PMC4775450
  • Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Stepp MA. K14 + compound niches are present on the mouse cornea early after birth and expand after debridement wounds. Developmental dynamics : an official publication of the American Association of Anatomists. 2016; 245(2):132-43. NIHMSID: NIHMS734678 PubMed [journal] PMID: 26515029, PMCID: PMC4715603
  • Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Kyne BM, Saban DR, Stepp MA. Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea. Laboratory investigation; a journal of technical methods and pathology. 2015; 95(11):1305-18. NIHMSID: NIHMS703215 PubMed [journal] PMID: 26280222, PMCID: PMC4626298
  • Stepp MA, Pal-Ghosh S, Tadvalkar G, Pajoohesh-Ganji A. Syndecan-1 and Its Expanding List of Contacts. Advances in wound care. 2015; 4(4):235-249. PubMed [journal] PMID: 25945286, PMCID: PMC4397989
  • Pajoohesh-Ganji A, Burns MP, Pal-Ghosh S, Tadvalkar G, Hokenbury NG, Stepp MA, Faden AI. Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury. Brain research. 2014; 1560:73-82. NIHMSID: NIHMS576081 PubMed [journal] PMID: 24630972, PMCID: PMC4129635
  • Pal-Ghosh S, Pajoohesh-Ganji A, Menko AS, Oh HY, Tadvalkar G, Saban DR, Stepp MA. Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury. Investigative ophthalmology & visual science. 2014; 55(4):2757-65. PubMed [journal] PMID: 24677104, PMCID: PMC4004424
  • Stepp MA, Zieske JD, Trinkaus-Randall V, Kyne BM, Pal-Ghosh S, Tadvalkar G, Pajoohesh-Ganji A. Wounding the cornea to learn how it heals. Experimental eye research. 2014; 121:178-93. NIHMSID: NIHMS578816 PubMed [journal] PMID: 24607489, PMCID: PMC4072315
  • Menko AS, Bleaken BM, Libowitz AA, Zhang L, Stepp MA, Walker JL. A central role for vimentin in regulating repair function during healing of the lens epithelium. Molecular biology of the cell. 2014; 25(6):776-90. PubMed [journal] PMID: 24478454, PMCID: PMC3952848
  • Keidar M, Shashurin A, Volotskova O, Stepp M, Srinivasan P, Sandler A, Trink B. Cold atmospheric plasma in cancer therapy. Physics of Plasmas. 2013; 20(5):057101. My Bibliography [journal]
  • Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Stepp MA. Corneal goblet cells and their niche: implications for corneal stem cell deficiency. Stem cells (Dayton, Ohio). 2012; 30(9):2032-43. NIHMSID: NIHMS398921 PubMed [journal] PMID: 22821715, PMCID: PMC3635098
  • Padmakumar VC, Speer K, Pal-Ghosh S, Masiuk KE, Ryscavage A, Dengler SL, Hwang S, Edwards JC, Coppola V, Tessarollo L, Stepp MA, Yuspa SH. Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice. The American journal of pathology. 2012; 181(1):74-84. PubMed [journal] PMID: 22613027, PMCID: PMC3388159
  • Volotskova O, Hawley TS, Stepp MA, Keidar M. Targeting the cancer cell cycle by cold atmospheric plasma. Scientific reports. 2012; 2:636. PubMed [journal] PMID: 22957140, PMCID: PMC3434394
  • Pal-Ghosh S, Pajoohesh-Ganji A, Tadvalkar G, Stepp MA. Removal of the basement membrane enhances corneal wound healing. Experimental eye research. 2011; 93(6):927-36. NIHMSID: NIHMS336272 PubMed [journal] PMID: 22067129, PMCID: PMC3443627
  • Blanco-Mezquita JT, Hutcheon AE, Stepp MA, Zieske JD. αVβ6 integrin promotes corneal wound healing. Investigative ophthalmology & visual science. 2011; 52(11):8505-13. PubMed [journal] PMID: 21960555, PMCID: PMC3208190
  • Pal-Ghosh S, Blanco T, Tadvalkar G, Pajoohesh-Ganji A, Parthasarathy A, Zieske JD, Stepp MA. MMP9 cleavage of the β4 integrin ectodomain leads to recurrent epithelial erosions in mice. Journal of cell science. 2011; 124(Pt 15):2666-75. PubMed [journal] PMID: 21750188, PMCID: PMC3138707
  • Velasco J, Li J, DiPietro L, Stepp MA, Sandy JD, Plaas A. Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling. The Journal of biological chemistry. 2011; 286(29):26016-27. PubMed [journal] PMID: 21566131, PMCID: PMC3138253
  • Stepp MA, Daley WP, Bernstein AM, Pal-Ghosh S, Tadvalkar G, Shashurin A, Palsen S, Jurjus RA, Larsen M. Syndecan-1 regulates cell migration and fibronectin fibril assembly. Experimental cell research. 2010; 316(14):2322-39. NIHMSID: NIHMS213918 PubMed [journal] PMID: 20580707, PMCID: PMC3141227
  • Stepp MA, Pal-Ghosh S, Tadvalkar G, Rajjoub L, Jurjus RA, Gerdes M, Ryscavage A,  Cataisson C, Shukla A, Yuspa SH. Loss of syndecan-1 is associated with malignant conversion in skin carcinogenesis. Molecular carcinogenesis. 2010; 49(4):363-73. NIHMSID: NIHMS469026 PubMed [journal] PMID: 20082322, PMCID: PMC3653623
  • Singh P, Chen C, Pal-Ghosh S, Stepp MA, Sheppard D, Van De Water L. Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. The Journal of investigative dermatology. 2009; 129(1):217-28. NIHMSID: NIHMS472637 PubMed [journal] PMID: 18633440, PMCID: PMC3681306
  • Pal-Ghosh S, Tadvalkar G, Jurjus RA, Zieske JD, Stepp MA. BALB/c and C57BL6 mouse strains vary in their ability to heal corneal epithelial debridement wounds. Experimental eye research. 2008; 87(5):478-86. NIHMSID: NIHMS78366 PubMed [journal] PMID: 18809399, PMCID: PMC2654715
  • Mayo C, Ren R, Rich C, Stepp MA, Trinkaus-Randall V. Regulation by P2X7: epithelial migration and stromal organization in the cornea. Investigative ophthalmology & visual science. 2008; 49(10):4384-91. NIHMSID: NIHMS77322 PubMed [journal] PMID: 18502993, PMCID: PMC2605938
  • Jurjus RA, Liu Y, Pal-Ghosh S, Tadvalkar G, Stepp MA. Primary dermal fibroblasts derived from sdc-1 deficient mice migrate faster and have altered alphav integrin function. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2008; 16(5):649-60. NIHMSID: NIHMS469027 PubMed [journal] PMID: 19128260, PMCID: PMC3664453
  • Tripathi BK, Stepp MA, Gao CY, Zelenka PS. The Cdk5 inhibitor olomoucine promotes corneal debridement wound closure in vivo. Molecular vision. 2008; 14:542-9. PubMed [journal] PMID: 18385789, PMCID: PMC2274924
  • Stepp MA, Liu Y, Pal-Ghosh S, Jurjus RA, Tadvalkar G, Sekaran A, Losicco K, Jiang L, Larsen M, Li L, Yuspa SH. Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1. Journal of cell science. 2007; 120(Pt 16):2851-63. PubMed [journal] PMID: 17666434
  • Vanhoutte D, Schellings MW, Götte M, Swinnen M, Herias V, Wild MK, Vestweber D, Chorianopoulos E, Cortés V, Rigotti A, Stepp MA, Van de Werf F, Carmeliet P, Pinto YM, Heymans S. Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction. Circulation. 2007; 115(4):475-82. PubMed [journal] PMID: 17242279
  • Stepp MA. Corneal integrins and their functions. Experimental eye research. 2006; 83(1):3-15. PubMed [journal] PMID: 16580666
  • Pajoohesh-Ganji A, Pal-Ghosh S, Simmens SJ, Stepp MA. Integrins in slow-cycling corneal epithelial cells at the limbus in the mouse. Stem cells (Dayton, Ohio).2006; 24(4):1075-86. PubMed [journal] PMID: 16282441
  • Hutcheon AE, Guo XQ, Stepp MA, Simon KJ, Weinreb PH, Violette SM, Zieske JD. Effect of wound type on Smad 2 and 4 translocation. Investigative ophthalmology & visual science. 2005; 46(7):2362-8. PubMed [journal] PMID: 15980223
  • Pajoohesh-Ganji A, Stepp MA. In search of markers for the stem cells of the corneal epithelium. Biology of the cell. 2005; 97(4):265-76. PubMed [journal] PMID: 15762848
  • Stepp MA, Zieske JD. The corneal epithelial stem cell niche. The ocular surface. 2005; 3(1):15-26. PubMed [journal] PMID: 17131002
  • Singh P, Reimer CL, Peters JH, Stepp MA, Hynes RO, Van De Water L. The spatial and temporal expression patterns of integrin alpha9beta1 and one of its ligands,  the EIIIA segment of fibronectin, in cutaneous wound healing. The Journal of investigative dermatology. 2004; 123(6):1176-81. PubMed [journal] PMID: 15610531
  • Gao CY, Stepp MA, Fariss R, Zelenka P. Cdk5 regulates activation and localization of Src during corneal epithelial wound closure. Journal of cell science. 2004; 117(Pt 18):4089-98. PubMed [journal] PMID: 15280426
  • Pajoohesh-Ganji A, Ghosh SP, Stepp MA. Regional distribution of alpha9beta1 integrin within the limbus of the mouse ocular surface. Developmental dynamics :  an official publication of the American Association of Anatomists. 2004; 230(3):518-28. PubMed [journal] PMID: 15188436
  • Pal-Ghosh S, Pajoohesh-Ganji A, Brown M, Stepp MA. A mouse model for the study of recurrent corneal epithelial erosions: alpha9beta1 integrin implicated in progression of the disease. Investigative ophthalmology & visual science. 2004; 45(6):1775-88. PubMed [journal] PMID: 15161840
  • Tomczuk M, Takahashi Y, Huang J, Murase S, Mistretta M, Klaffky E, Sutherland A, Bolling L, Coonrod S, Marcinkiewicz C, Sheppard D, Stepp MA, White JM. Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3. Experimental cell research. 2003; 290(1):68-81. PubMed [journal] PMID: 14516789
  • Stepp MA, Gibson HE, Gala PH, Iglesia DD, Pajoohesh-Ganji A, Pal-Ghosh S, Brown M, Aquino C, Schwartz AM, Goldberger O, Hinkes MT, Bernfield M. Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse. Journal of cell science. 2002; 115(Pt 23):4517-31. PubMed [journal] PMID: 12414997
  • Belkin AM, Stepp MA. Integrins as receptors for laminins. Microscopy research and technique. 2000; 51(3):280-301. PubMed [journal] PMID: 11054877
  • Sta Iglesia DD, Stepp MA. Disruption of the basement membrane after corneal débridement. Investigative ophthalmology & visual science. 2000; 41(5):1045-53. PubMed [journal] PMID: 10752940
  • Sta Iglesia DD, Gala PH, Qiu T, Stepp MA. Integrin expression during epithelial migration and restratification in the tenascin-C-deficient mouse cornea. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2000; 48(3):363-76. PubMed [journal] PMID: 10681390