Research Projects

Epigenetic progression model of pancreatic cancer diagramEpigenetic progression model of pancreatic cancer.

We seek to define the core epigenetic programs that co-operate with genetic alterations to drive pancreatic cancer initiation and maintenance.

Epigenetic regulation of Hematopoietic Stem Cells diagramEpigenetic regulation of Hematopoietic Stem Cells.

Using new genetically engineered mouse models we are studying the role of KDM2B in leukemias and in the self-renewal and differentiation potential of hematopoietic stem cells.

Cross-talk of signaling pathways and the epigenetic machinery diagramCross-talk of signaling pathways and the epigenetic machinery.

We are interested in uncovering the signaling pathways that regulate the activity and targeting of histone demethylases.

Gene discovery diagram

Gene discovery.

We use Sleeping Beauty transposon mediated mutagenesis for unbiased, forward genetic screens to discover genes that co-operate  with histone modifying enzymes to drive oncogenesis in vivo.