WE-HEAL Study - Wound Microbiome Project

Research Question: What effect does the wound microbiome have on wound healing?

Significance Aims
  • 60% of chronic wounds are coated in biofilm
  • Biofilms prevent clearance of bacteria by antibiotics
  • Biofilms alter the host immune response
  • Define the bacterial profile in healing compared to recalcitrant wounds
  • Gain insights into the interaction between wound microbiome and host immune pathways
  • Correlate the microbiome profile with host immune response, pain, comorbidities, and outcome
  • Identify potential new therapeutic approaches