Significance Aims Delayed wound healing is a well-recognized complication of scleroderma Chronic wounds are a major cause of morbidity in scleroderma Scleroderma patient's wounds take longer to heal than patients without scleroderma To identify differences in molecular mechanisms of wound healing in scleroderma compared to other chronic wounds To investigate interplay of host immune response and wound bed microbiome in patients with scleroderma To identify therapies and treatments for scleroderma associated chronic wounds
