Wound Healing in Scleroderma

Research Question: What impact does scleroderma have on wound healing?

Significance Aims
  • Delayed wound healing is a well-recognized complication of scleroderma
  • Chronic wounds are a major cause of morbidity in scleroderma
  • Scleroderma patient's wounds take longer to heal than patients without scleroderma
  • To identify differences in molecular mechanisms of wound healing in scleroderma compared to other chronic wounds
  • To investigate interplay of host immune response and wound bed microbiome in patients with scleroderma
  • To identify therapies and treatments for scleroderma associated chronic wounds