STOP Scleroderma Study

STOP Scleroderma

Scleroderma is a heterogeneous disease causing inflammation, damaged blood vessels, and fibrosis of tissues and internal organs. 

Scleroderma:

  • Affects about 100,000 Americans
  • Is most common in women and certain ethnic groups
  • African Americans have more severe disease and worst outcomes
  • Affects multiple organs and contribute to end organ damage
  • There is currently no cure

There is an unmet need to tailor individualized therapies for scleroderma patients.


Diffuse Scleroderma          Genomics in Scleroderma          Wound Healing in Scleroderma


Publications

A 66 year-old woman with hemoptysis. Patel FB, Couch KS, McNish S, Miller JD, Siegel R, Easley S, Shanmugam VKArthritis Care Res (Hoboken). 2015 Dec 29. doi: 10.1002/acr.22820.

Cardiac metabolomics and autopsy in a patient with early diffuse systemic sclerosis presenting with dyspnea: a case report. Frech TM, Revelo MP, Ryan JJ, Shah AA, Gordon J, Domsic R, Hant F, Assassi S, Shanmugam VK, Hinchcliff M, Steen V, Khanna D, Bernstein EJ, Cox J, Luem N, Drakos S. J Med Case Rep. 2015 Jun 10;9(1):136.

Treatment of early diffuse systemic sclerosis skin disease. Frech TM, Shanmugam VK, Shah AA, Assassi S, Gordon JK, Hant FN, Hinchcliff ME, Steen V, Khanna D, Kayser C, Domsic RT. Clin Exp Rheumatol. 2013 Mar-Apr;31(2 Suppl 76):166-71. Epub 2013 Jul 23. Review. PMID: 23910619

Renal disease in scleroderma: an update on evaluation, risk stratification, pathogenesis and management. Shanmugam VK, Steen VD. Curr Opin Rheumatol. 2012 Nov;24(6):669-76. Review. PMID: 22955019

Comparison of indirect immunofluorescence and multiplex antinuclear antibody screening in systemic sclerosis. Shanmugam VK, Swistowski DR, Saddic N, Wang H, Steen VD. Clin Rheumatol. 2011 Oct;30(10):1363-8. doi: 10.1007/s10067-011-1766-6. Epub 2011 May 27. PMID: 21614475

Lower extremity ulcers in systemic sclerosis: features and response to therapy. Shanmugam VK, Price P, Attinger CE, Steen VD. Int J Rheumatol. 2010;2010. pii: 747946. doi: 10.1155/2010/747946. Epub 2010 Aug 18. PMID: 20827313

Renal manifestations in scleroderma: evidence for subclinical renal disease as a marker of vasculopathy. Shanmugam VK, Steen VD. Int J Rheumatol. 2010;2010. pii: 538589. doi: 10.1155/2010/538589. Epub 2010 Aug 17. PMID: 20827302

Exercise-induced pulmonary arterial hypertension in patients with systemic sclerosis. Steen V, Chou M, Shanmugam V, Mathias M, Kuru T, Morrissey R. Chest. 2008 Jul;134(1):146-51. doi: 10.1378/chest.07-2324. Epub 2008 Apr 10. PMID:18403670