Collaborating Sites and Partnerships


The MITM-CRG has a long-standing relationship with researchers at the Centro de Pesquisas René Rachou (CPqRR) – a part of the Brazilian federal Oswaldo Cruz Foundation (FIOCRUZ) in the city of Belo Horizonte, Minas Gerais. 

CPqRR – FIOCRUZ has for the past several years conducted research into the understanding of the role of the immune response in the development of pathology in individuals infected with hookworm, Schistosoma mansoni, Ascaris lumbricoides, Dengue, Leishmania, leptospirosis, Toxoplasma gondii, and malaria, among other neglected tropical diseases (NTD). 

Together with MITM researchers, the CPqRR has established a field study site in Americaninhas, located in a rural area of the northeast region of the Brazilian state of Minas Gerais. The field site includes a vaccine-testing center in the town for the conduct of vaccine and other clinical trials.

Location of the clinical trial site: 

The trial site is located in the town of Americaninhas (inset) in the Brazilian state of Minas Gerais (MG).  The clinical trial outpatient clinic building is shown in the lower left inset.


Developing and Testing of a novel, low-cost, effective HOOKworm VACcine to Control Human Hookworm Infection in endemic countries (HOOKVAC).

HOOKVAC, a consortium of global partners across the United States, Europe, and sub-Saharan Africa, with funding from the European Commission FP7 program, will build on previous clinical development by beginning the first clinical testing of the human hookworm vaccine in the West African nation of Gabon.

HOOKVAC conducted a phase 1 clinical trial in which the separately-formulated Na-GST-1 and Na-APR-1 antigens are co-administered in adults and to validate the safety and immunogenicity of these antigens and explore the optimal doses and vaccination schedule in an endemic African population.  This was conducted in Lambaréné, Gabon, which is a typical setting within the Central African rainforest belt. The prevalence of hookworm infection in Lambaréné is around 30%. Following completion of this study in adults, a co-administration study in school-aged children was initiated in February 2017. 

Global Health Clinical Consortium

We are a member of the Global Health Clinical Consortium, funded by the Bill & Melinda Gates Foundation.  This consortium, a collaboration of several Product Development Partnerships (PDPs), was established to foster innovation and efficiencies through sharing of information and resources.