Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC). Proposed studies may help define new molecular biomarkers of HCV-infection associated liver cancer. The functional validation of miRNA and their targets may delineate progressive stages of HCV-induced liver cancer and help in the development of new therapy reagents. This is an excellent proposal with high significance.
The proposed study may help define new biomarkers of HCV-induced liver cancer. The PI should be able to get some preliminary data to support his future RO1 application.