Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC). Proposed studies may help define new molecular biomarkers of HCV-infection associated liver cancer.
The currently accepted stepwise model of breast tumorigenesis assumes a gradual transition from epithelial hyperproliferation (including ADH) to ductal carcinoma in situ(DCIS) and then to invasive ductal carcinoma (IDC). This progression model is strongly supported by clinical and epidemiological data and by molecular clonally studies.
Glioblastoma is a highly malignant primary central nervous system neoplasm associated with poor survival and is invariably fatal. Recurrence in glioblastoma typically occurs locally, prompting the development of treatment that provides post-operative intracavitary delivery.
To identify gene expression and splice variation differences in colon cancer between African-American (AA) and Caucasian-American (CA) patients in an aim to investigate differences in the natural progression of the disease between the two racial populations.
Multiple myeloma (MM), an incurable clonal plasma cell disorder, is the second most common hematologic malignancy in the United States with over 20,000 new cases and 10,000 deaths each year. Although many chemotherapeutic drugs display cytotoxic activity toward MM cells, MM patients inevitably relapse.
The objective of this collaborative research proposal is to develop a contrast aided sonographic diagnosis of thyroid cancer using subharmonic contrast imaging (imaging at half the excitation frequency). Although thyroid nodules are found in 30-70% of the adult population, only 5-7% of them are malignant that needs surgical intervention.