This proposal is a request for an additional stage of funding for our previously funded Katzen project to develop a cancer imaging and treatment probe that integrates optical coherence tomography (OCT) for imaging and cold plasmas for selective plasma treatment.

This proposal aims to define the genetic and expression background accompanying BRCA1 and BRCA2 pathogenic mutations in individuals who have not developed an early onset cancer, in comparison with mutation carriers with an early onset disease.

Objective is to conduct formative work to assess rates and patterns of cancer screening to inform the development and feasibility of communication technologies to assist cancer care teams. The goal is to increase provider awareness of cancer screening guidelines, 2) increase cancer screenings, and 3) promote care coordination.