Research Support

Our laboratory tests the efficacy of newly developed drugs and nutrichemicals to treat hypertension in mice that are genetically altered to either not express endogenous murine genes (knockouts) or express human genes (knockins, transgenics) that regulate blood pressure. 


R37HL023081, Renal dopamine receptor regulation and function. The major goal of this project is to determine the role of sorting nexins in the regulation of D1 and D5 dopamine receptors in the kidney. This grant has been funded by the National Institutes of Health for 37 years.
 

R01DK039308, Renal dopamine-1 receptor defect in hypertension. The major goal of this project is to determine how the gastro-renal reflex regulates sodium balance and blood pressure. This grant has been funded by the National Institutes of Health for 30 years.
 

R01HL092196, G protein-coupled receptor kinase type 4 and development of salt sensitivity. The major goal of this project is to study the mechanisms by which the GRK4 486V gene promotes salt sensitivity while the GRK4 wild-type gene promotes salt resistance. This grant has been funded by the National Institutes of Health for 9 years.
 

P01HL068686, Renal vascular oxidative stress in hypertension. This is a program project grant directed by Dr. Christopher S. Wilcox, Georgetown University School of Medicine. There are three projects in this program project grant. The major goal of our project (subproject #3) is to determine the mechanisms by which the D2 dopamine receptor regulates reactive oxygen species. This grant has been funded by the National Institutes of Health for 14 years.
 

P01HL074940, Molecular mechanisms in salt sensitivity of blood pressure. This is a program project grant directed by Dr. Robin A. Felder, The University of Virginia School of Medicine There are three projects in this program project grant. The major goal of our project (subproject #3 ) is to test the hypothesis that in some cases of salt-sensitive hypertension, GRK4ɣ-65L and intronic variants of SLC4A5 increase SLC4A5 expression in response to aberrant genetic regulation of epigenetic pathways that also increase renal NHE3 and Cl-/HCO3- exchanger activities. This grant has been funded by the National Institutes of Health for 11 years.
 

R01DK090918, Role of D2 dopamine receptor in renal inflammation and injury. The major goal of this project is to test the hypothesis that the D2 dopamine receptor regulates the inflammatory reaction in the kidney and that impaired function of the D2 dopamine receptor results in renal inflammation and end-organ damage. This grant has been funded by the National Institutes of Health for 8 years.