Meet the PI

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R. Brad Jones, Ph.D.
Assistant Professor of Microbiology, Immunology and Tropical Medicine

Brad Jones, Ph.D., joined the George Washington University in May 2015 as Assistant Professor in the Department of Microbiology, Immunology and Tropical Medicine. He is an immunovirologist with considerable experience in studying the cellular immune response to acute and chronic HIV infection.

Dr. Jones received his Bachelor’s degree in Molecular Biology from Simon Fraser University in Vancouver in 2004. During his graduate studies in the laboratory of Dr. Mario Ostrowski at the University of Toronto, he identified a novel mechanism by which HIV infection drives immune cell dysfunction (Tim-3), and explored human endogenous retroviruses (HERVs) as novel targets for HIV vaccines.

After obtaining a Ph.D. in Immunology in 2011, Dr. Jones left Canada and joined the laboratories of Drs. Bruce Walker and Darrell Irvine at the Ragon Institute of MGH, MIT and Harvard in Boston as a Banting Fellow. During his post-doctoral studies at the Ragon Institute, he discovered that the histone deacetylase inhibitors under development for HIV cure therapeutics have the potential to impair the abilities of HIV-specific T-cells to eliminate infected cells. He went on to develop and refine a number of novel assays to assess the impacts of latency reversing agents on T-cell function, and worked on harnessing a new technology to enhance the ability of T cells to detect and kill latently HIV infected cells.

Dr. Jones has now embarked upon an independent research career as an Assistant Professor at MITM, where he intends to leverage his past experience to study means by which to optimally harness cytotoxic T-cell responses to contribute to HIV eradication.

Honors and Awards

2013

Banting Postdoctoral Fellowship, Canadian Institutes of Health Research

2013

New Investigator Award, CROI, Atlanta, GA

2012

Junior Investigator Development Award, Ontario HIV Treatment Network

2011

New Investigator Award, Canadian Association for HIV Research, Toronto, Canada

2011

Basic Sciences Scholarship Award, Canadian Association for HIV Research, Toronto, Canada

2010

Richard Miller Award, Department of Immunology, University of Toronto, Toronto, Canada

2010

New Investigator Award, Keystone Symposium on HIV Vaccines, Banff, Canada

2009

Studentship Award, Ontario HIV Treatment Network

2009

New Investigator Award, Keystone Symposium on HIV Vaccines, Keystone, Colorado

2008

New Investigator Award, Keystone Symposium on HIV Vaccines, Whistler, Canada

2008

New Investigator Award, International AIDS Vaccine Initiative, Capetown, South Africa

2008

Poster Competition Award, Ontario HIV Treatment Network Conference, Toronto, Canada

2007

New Investigator Award, Canadian Association for HIV Research, Toronto, Canada

2007

New Investigator Award, Keystone Symposium on HIV Vaccines, Banff, Canada

2006

Ontario HIV Treatment Network Studentship Award

2006

New Investigator Award, CROI, Los Angeles, CA

2005

Ontario Graduate Scholarship

2002

Natural Sciences Engineering and Research Council, Undergraduate Student Research Award

1999

Gordon M. Shrum Memorial Entrance Scholarship, Simon Fraser University, Vancouver, Canada

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Previous Contributions to Science

A. Probing the role of endogenous retro-elements in HIV pathogenesis / targeting endogenous retroviruses as an alternative HIV vaccine strategy

1. Jones RB, Song H, Xu Y, Garrison KE, Buzdin AA, Anwar N, Hunter DV, Mujib S, Mihajlovic V, Martin E, Lee E, Kuciak M, Raposo RA, Bozorgzad A, Meiklejohn DA, Ndhlovu LC, Nixon DF, Ostrowski MA.
LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells.
J Virol. 2013 Dec;87(24):13307-20. PMCID: PMC3838212

2. Jones RB, Garrison KE, Mujib S, Mihajlovic V, Aidarus N, Hunter DV, Martin E, John VM, Zhan W, Faruk NF, Gyenes G, Sheppard NC, Priumboom-Brees IM, Goodwin DA, Chen L, Rieger M, Muscat-King S, Loudon PT, Stanley C, Holditch SJ, Wong JC, Clayton K, Duan E, Song H, Xu Y, SenGupta D, Tandon R, Sacha JB, Brockman MA, Benko E, Kovacs C, Nixon DF, Ostrowski MA.
HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates.
J Clin Invest. 2012 Dec;122(12):4473-89. PMCID: PMC3533534

3. Jones RB*, Garrison KE*, Meiklejohn DA, Anwar N, Ndhlovu LC, Chapman JM, Erickson AL, Agrawal A, Spotts G, Hecht FM, Rakoff-Nahoum S, Lenz J, Ostrowski MA, Nixon DF.
T cell responses to human endogenous retroviruses in HIV-1 infection.
PLoS Pathog. 2007 Nov;3(11):e165. PMCID: PMC2065876  *co-first authors

4. Jones RB, Garrison KE, Wong JC, Duan EH, Nixon DF, Ostrowski MA.
Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition.
PLoS One. 2008 Feb;3(2):e1547. PMCID: PMC2212136

B. Identification of a role for Tim-3 in T-cell exhaustion

1. Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, Wong JC, Satkunarajah M, Schweneker M, Chapman JM, Gyenes G, Vali B, Hyrcza MD, Yue FY, Kovacs C, Sassi A, Loutfy M, Halpenny R, Persad D, Spotts G, Hecht FM, Chun TW, McChune JM, Kaul R, Rini JM, Nixon DF, Ostrowski MA.
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.
J Exp Med. 2008 Nov;205(12):2763-79 PMCID: PMC2585847

2. Vali B, Jones RB, Sakhdari A, Sheth PM, Clayton K, Yue FY, Gyenes G, Wong D, Klein MB, Saeed S, Benko E, Kovacs C, Kaul R, Ostrowski MA.
HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression.
Eur J Immunol. 2010 Sep;40(9):2493-505 PMID 20623550

3. Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA.
Antigen-independent induction of Tim-3 expression on human T cells by the common –chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway.
J Immunol. 2012 Apr;188(8):3745-56 PMID: 22422881

4. Sakhdari A, Mujib S, Vali B, Yue FY, MacParland S, Clayton K, Jones RB, Liu J, Lee EY, Benko E, Kovacs C, Gommerman J, Kaul R, Ostrowski MA.
Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection.
PLoS One. 2012 7(7):e40146. PMCID: PMC3390352

C. Harnessing cytotoxic T-lymphocytes for ‘shock and kill’ HIV eradication strategies

1. Jones RB, O’Connor R, Mueller S, Foley M, Szeto GL, Karel D, Lichterfeld M, Kovacs C, Ostrowski MA, Trocha A, Irvine DJ, Walker BD.
Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes.
PLoS Pathog. 2014 10(8):e1004287. PMCID: PMC4133386

2. Anmole G, Kuang XT, Toyoda M, Martin E, Shahid A, Le AQ, Markle T, Baraki B, Jones RB, Ostrowski MA, Ueno T, Brumme ZL, Brockman MA.
A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion.
J Immunol Methods. 2015 1759(15):30037-5. PMCID: pending.

3. Brockman MA, Jones RB, Brumme ZL.
Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs.
Front Immunol. 2015 6:506. PMCID: PMC4591506

4. Jones RB, Walker BD.
HIV-specific CD8+ T-cells and HIV eradication.
J Clin Invest. 2016 Jan 5:1-9. Review. [Epub ahead of print]

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