Publications

Please visit ncbi.nlm.nih.gov to access John M. Hawdon's full bibliography

Diemert D, Campbell D, Brelsford J, Leasure C, Li G, Peng J, Zumer M, Younes N, Bottazzi ME, Mejia R, Pritchard DI, Hawdon JM, Bethony JM. Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development. Open Forum Infect Dis. 2018 May;5(5):ofy083.  PMID: 29780848; PMCID: PMC5952933.

Magrini V, Gao X, Rosa BA, McGrath S, Zhang X, Hallsworth-Pepin K, Martin J, Hawdon JM, Wilson RK, Mitreva M.
Improving eukaryotic genome annotation using single molecule mRNA sequencing.
BMC Genomics. 2018 Mar 01;19(1):172.

Weeks JC, Roberts WM, Leasure C, Suzuki BM, Robinson KJ, Currey H, Wangchuk P, Eichenberger RM, Saxton AD, Bird TD, Kraemer BC, Loukas A, Hawdon JM, Caffrey CR, Liachko NF.
Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing.
Sci Rep. 2018 Jan 17;8(1):975.

Feather CM, Hawdon JM, March JC.
Ancylostoma ceylanicum infective third-stage larvae are activated by co-culture with HT-29-MTX intestinal epithelial cells. 
Parasit Vectors. 2017 Dec 15;10(1):606.

Vadnal, J, Ratnappan, R, Keaney, M, Kenney, E, Eleftherianos, I, O’Halloran, D, Hawdon, JM.
Identification of candidate infection genes from the model entomopathogenic nematode Heterorhabditis bacteriophora.
BMC Genomics. 2017 Jan 3;18(1):8.

Weeks, JC, Roberts, WM, Robinson, KJ, Keaney, M, Vermeire, JJ, Urban,JF Jr., Lockery, SR, Hawdon, JM.
Microfluidic platform for electrophysiological recordings from host-stage hookworm and Ascaris suum larvae: A new tool for anthelmintic research. 
Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):314-328.

Hawdon JM.
Acceptance of the 2016 Henry Baldwin Ward Medal – a long and winding road to a Diet of Worms.
J Parasitol. 2016 Dec;102(6):579-586.

Cook, JA, Greiman, SE, Agosta, SJ, Anderson, RP, Arbogast, BS, Baker, RJ, Boeger, W, Bradley, RD, Brooks, DR, Cole, R, Demboski, JR, Dobson, AP, Dunnum, JL, Eckerlin, RP, Esselstyn, J, Galbreath, KE, Hawdon, J, Hoekstra, HE, Kutz, SJ, Light, JE, Olson, LE, Patterson, BD, Patton, JL, Phillips, AJ, Rickart, E, Rogers, DS, Siddall, ME, Tkach, VV, Hoberg, EP.
Transformational Principles for NEON Sampling of Mammalian Parasites and Pathogens: A Response to Springer and Colleagues.
BioScience. 2016 Nov 1;66(11): 917-919.

Ratnappan R, Vadnal J, Keaney M, Eleftherianos I, O'Halloran D, Hawdon JM
RNAi-mediated gene knockdown by microinjection in the model entomopathogenic nematode Heterorhabditis bacteriophora.
Parasit Vectors. 2016 Mar 18;9(1):160.

Gelmedin V, Delaney A, Jennelle L, Hawdon JM.
Expression profile of heat shock response factors during hookworm larval activation and parasitic development.
Mol Biochem Parasitol. 2015 Jul;202(1):1-14.

Gao  X, Goggin  K, Dowling  C, Qian  J, Hawdon JM.
Two potential hookworm DAF-16 target genes, SNR-3 and LPP-1: gene structure, expression profile, and implications of a cis -regulatory element in the regulation of gene expression.
Parasit Vectors. 2015 Jan; 8:14

Hawdon JM.
Controlling soil-transmitted helminths: time to think inside the box?
J Parasitol. 2014 Apr;100(2):166-88. Review.

Tang YT, Gao X, Rosa BA, Abubucker S, Hallsworth-Pepin K, Martin J, Tyagi R, Heizer E, Zhang X, Bhonagiri-Palsikar V, Minx P, Warren WC, Wang Q, Zhan B, Hotez PJ, Sternberg PW, Dougall A, Gaze ST, Mulvenna J, Sotillo J, Ranganathan S, Rabelo EM, Wilson RK, Felgner PL, Bethony J, Hawdon JM, Gasser RB, Loukas A, Mitreva M.
Genome of the human hookworm Necator americanus.
Nat Genet. 2014 Mar;46(3):261-9.

Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, Xu HE.
Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes.
J Biol Chem. 2012 Feb10;287(7):4894-903.

Dryanovski DI, Dowling C, Gelmedin V, Hawdon JM.
RNA and protein synthesis is required for Ancylostoma caninum larval activation.
Vet Parasitol. 2011 Jun30;179(1-3):137-43.

Krepp J, Gelmedin V, Hawdon JM.
Characterisation of hookworm heat shock factor binding protein (HSB-1) during heat shock and larval activation.
Int J Parasitol.2011 Apr;41(5):533-43.

Gelmedin V, Brodigan T, Gao X, Krause M, Wang Z, Hawdon JM.
Transgenic C. elegans dauer larvae expressing hookworm phospho null DAF-16/FoxO exit dauer.
PLoS One. 2011;6(10):e25996.

Weaver HJ, Hawdon JM, Hoberg EP.
Soil-transmitted helminthiases: implications of climate change and human behavior.
Trends Parasitol. 2010 Dec;26(12):574-81.

Gao X, Wang Z, Martin J, Abubucker S, Zhang X, Mitreva M, Hawdon JM.
Identification of hookworm DAF-16/FOXO response elements and direct gene targets.
PLoS One. 2010 Aug 19;5(8):e12289.

Wang Z, Abubucker S, Martin J, Wilson RK, Hawdon J, Mitreva M.
Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation.
BMC Genomics. 2010 May 14;11:307.

Wang Z, Zhou XE, Motola DL, Gao X, Suino-Powell K, Conneely A, Ogata C, Sharma KK, Auchus RJ, Lok JB, Hawdon JM, Kliewer SA, Xu HE, Mangelsdorf DJ.
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9138-43.

Kiss JE, Gao X, Krepp JM, Hawdon JM.
Interaction of hookworm 14-3-3 with the forkhead transcription factor DAF-16 requires intact Akt phosphorylation sites.
Parasit Vectors. 2009 Apr 24;2(1):21.

Gao X, Frank D, Hawdon JM.
Molecular cloning and DNA binding characterization of DAF-16 orthologs from Ancylostoma hookworms.
Int J Parasitol. 2009 Mar;39(4):407-15.

Wolpert BJ, Beauvoir MG, Wells EF, Hawdon JM.
Plant vermicides of Haitian Vodou show in vitro activity against larval hookworm.
J Parasitol. 2008 Oct;94(5):1155-60.

Abubucker S, Martin J, Yin Y, Fulton L, Yang SP, Hallsworth-Pepin K, Johnston JS, Hawdon J, McCarter JP, Wilson RK, Mitreva M.
The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences.
Mol Biochem Parasitol. 2008 Feb;157(2):187-92.

Brand AM, Varghese G, Majewski W, Hawdon JM.
Identification of a DAF-7 ortholog from the hookworm Ancylostoma caninum.
Int J Parasitol. 2005 Dec;35(14):1489-98.

Zhan B, Liu S, Perally S, Xue J, Fujiwara R, Brophy P, Xiao S, Liu Y, Feng J, Williamson A, Wang Y, Bueno LL, Mendez S, Goud G, Bethony JM, Hawdon JM, Loukas A, Jones K, Hotez PJ. 
Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum.
Infect Immun. 2005 Oct;73(10):6903-11.

Mitreva M, McCarter JP, Arasu P, Hawdon J, Martin J, Dante M, Wylie T, Xu J, Stajich JE, Kapulkin W, Clifton SW, Waterston RH, Wilson RK.
Investigating hookworm genomes by comparative analysis of two Ancylostoma species.
BMC Genomics. 2005 Apr 26;6:58.

Delaney A, Williamson A, Brand A, Ashcom J, Varghese G, Goud GN, Hawdon JM.
Cloning and characterisation of an aspartyl protease inhibitor (API-1) from Ancylostoma hookworms.
Int J Parasitol. 2005 Mar;35(3):303-13.

Li TH, Guo XR, Xue J, Hu L, Qiang HQ, Xue HC, Bin Z, Hawdon JM, Xiao SH.
Comparison of mitochondrial cytochrome oxidase 1 DNA sequences from Necator americanus hookworms maintained for 100 generations in golden hamsters (Mesocricetus auratus) and hookworms from natural human infections.
Acta Trop. 2004 Sep;92(1):71-5.

Zhan B, Wang Y, Liu Y, Williamson A, Loukas A, Hawdon JM, Xue HC, Xiao SH, Hotez PJ. 
Ac-SAA-1, an immunodominant 16 kDa surface-associated antigen of infective larvae and adults of Ancylostoma caninum.
Int J Parasitol. 2004 Aug;34(9):1037-45.

Brand A, Hawdon JM.Phosphoinositide-3-OH-kinase inhibitor LY294002 prevents activation of Ancylostoma caninum and Ancylostoma ceylanicum third-stage infective larvae. Int J Parasitol. 2004 Jul;34(8):909-14.

Loukas A, Bethony JM, Williamson AL, Goud GN, Mendez S, Zhan B, Hawdon JM, Elena Bottazzi M, Brindley PJ, Hotez PJ. 
Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms.
J Infect Dis. 2004 May 15;189(10):1952-61.

Goud GN, Zhan B, Ghosh K, Loukas A, Hawdon J, Dobardzic A, Deumic V, Liu S, Dobardzic R, Zook BC, Jin Q, Liu Y, Hoffman L, Chung-Debose S, Patel R, Mendez S, Hotez PJ. 
Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicum.
J Infect Dis. 2004 Mar 1;189(5):919-29.

Hotez PJ, Zhan B, Bethony JM, Loukas A, Williamson A, Goud GN, Hawdon JM, Dobardzic A, Dobardzic R, Ghosh K, Bottazzi ME, Mendez S, Zook B, Wang Y, Liu S, Essiet-Gibson I, Chung-Debose S, Xiao S, Knox D, Meagher M, Inan M, Correa-Oliveira R, Vilk P, Shepherd HR, Brandt W, Russell PK.
Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative.
Int J Parasitol. 2003 Sep 30;33(11):1245-58. Review.

Zhan B, Liu Y, Badamchian M, Williamson A, Feng J, Loukas A, Hawdon JM, Hotez PJ.
Molecular characterisation of the Ancylostoma-secreted protein family from the adult stage of Ancylostoma caninum.
Int J Parasitol. 2003 Aug;33(9):897-907.

Hotez PJ, Ashcom J, Zhan B, Bethony J, Loukas A, Hawdon J, Wang Y, Jin Q, Jones KC, Dobardzic A, Dobardzic R, Bolden J, Essiet I, Brandt W, Russell PK, Zook BC, Howard B, Chacon M.
Effect of vaccination with a recombinant fusion protein encoding an astacinlike metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvae.
J Parasitol. 2003 Aug;89(4):853-5.

Hawdon JM, Datu B.
The second messenger cyclic GMP mediates activation in Ancylostoma caninum infective larvae.
Int J Parasitol. 2003 Jul 30;33(8):787-93.

Hawdon JM, Datu B, Crowell M.
Molecular cloning of a novel multidomain Kunitz-type proteinase inhibitor from the hookworm Ancylostoma caninum.
J Parasitol. 2003 Apr;89(2):402-7.

Basavaraju SV, Zhan B, Kennedy MW, Liu Y, Hawdon J, Hotez PJ.
Ac-FAR-1, a 20 kDa fatty acid- and retinol-binding protein secreted by adult Ancylostoma caninum hookworms: gene transcription pattern, ligand binding properties and structural characterisation.
Mol Biochem Parasitol. 2003 Jan;126(1):63-71. Erratum in: Mol Biochem Parasitol. 2010 Oct;173(2):175. Basavaraju, Sridhar [corrected to Basavaraju, Sridhar V].

Li TH, Guo XR, Hu L, Xiao SH, Xue HC, Hawdon J.
[Polymorphism analysis of cytochrome C oxidase 1 (COI) gene in Necator americanus collected from 5 provinces in China].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2003;21(4):210-3. Chinese.

Bethony J, Chen J, Lin S, Xiao S, Zhan B, Li S, Xue H, Xing F, Humphries D, Yan W, Chen G, Foster V, Hawdon JM, Hotez PJ. 
Emerging patterns of hookworm infection: influence of aging on the intensity of Necator infection in Hainan Province, People's Republic of China.
Clin Infect Dis. 2002 Dec 1;35(11):1336-44.

Hotez PJ, Ashcom J, Bin Z, Bethony J, Williamson A, Hawdon JM, Jianjun F, Dobardzic A, Rizo I, Bolden J, Jin Q, Yan W, Dobardzic R, Chung-Debose S, Crowell M, Datu B, Delaney A, Dragonovski D, Jiang Y, Yueyuan L, Ghosh K, Loukas A, Brandt W, Russell PK, Zook BC.
Effect of vaccinations with recombinant fusion proteins on Ancylostoma caninum habitat selection in the canine intestine.
J Parasitol. 2002 Aug;88(4):684-90.

Zhan B, Hotez PJ, Wang Y, Hawdon JM.
A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases.
Mol Biochem Parasitol. 2002 Apr 9;120(2):291-6.

Zhan B, Badamchian M, Meihua B, Ashcom J, Feng J, Hawdon J, Shuhua X, Hotez PJ.
Molecular cloning and purification of Ac-TMP, a developmentally regulated putative tissue inhibitor of metalloprotease released in relative abundance by adult Ancylostoma hookworms.
Am J Trop Med Hyg. 2002 Mar;66(3):238-44.