The Clinical Research Program conducts studies aimed at the prevention of disease and injury by early identification of risk factors, the mitigation of the negative health consequences of disease and injury through comparative effectiveness research and the provision of treatments that quicken recovery and reduce disability. Below is a summary of current clinical research projects being conducted in our department.
| Current Clinical Research Projects in the George Washington University Emergency Department | |||
|---|---|---|---|
Study Name |
Principal Investigator |
Coordinator |
Brief Project Description |
| ACTIV-6 | Dr. Andrew Meltzer | Soroush Shahamatdar |
ACTIV-6 study is a platform protocol designed to evaluate multiple repurposed oral medications for non-hospitalized participants with mild to moderate SARS-CoV-2 infection suitable for a wide range of settings within healthcare systems and in community settings where it can be integrated in subsequent treatment plans. Link for more information: https://activ6study.org/ |
| HYPERACT | Dr. David Yamane and Dr. Andrew Meltzer | Soroush Shahamatdar | This is a randomized control trial to determine effectiveness of high flow nasal canula relative to standard BIPAP for patients with COPD |
| QUALCOMM | Dr. Neal Sikka | David Li |
A pilot study and needs assessment on the use of Digital Health in households with barriers to technology and a history of hypertension. Link for more information: https://healthdesk.smhs.gwu.edu/about-us |
| Ultrasound versus palpation to locate the crichothyroid membrane in the ED: A randomized trial | Dr. Keith Boniface and Dr. Jordan Dow | This is a randomized blinded prospective trial comparing the accuracy of palpation to identify the cricothyroid membrane (CTM) compared with ultrasound location of the CTM, using the reference standard of CT to determine accuracy. | |
| Cannabanoid Hyperemesis Syndrome | Dr. Andrew Meltzer | Soroush Shahamatdar | This is a prospective observational study to evaluate current management and symptom resolution of emergency department patients who present with Cannabanoid Hyperemesis Syndrome. |
| Risk Factors and Health Care Utilization for Abdominal Pain Treated in the Emergency Department (RECURRENT) | Dr. Andrew Meltzer | Soroush Shahamatdar | A multicenter observational study focused on identifying factors predisposing to or associated with repeat emergency department presentations for functional abdominal pain. |
| Urgent Care Management of Respiratory Illness Enabled with Novel Testing Pathway (URGENT): A Randomized Controlled Trial of Respiratory PCR versus Standard Care | Dr. Andrew Meltzer | Aditya Loganathan | This is a randomized controlled trial examining the use of the BioFire PCR Respiratory Panel versus standard care procedures in patients with respiratory illness symptoms who seek care at our Immediate and Primary Care facilities. |
| Enhancing U.S. Surveillance of Laboratory Confirmed SARS-CoV-2, Influenza, and other Respiratory Viruses through a Network of Emergency Departments (RECOVER CDC) | Dr. Andrew Meltzer | Meylakh Barshay | Multi-site, ED surveillance study which provides CDC and states with critical information necessary to determine rates of respiratory illness in ED settings and the percent of specimens testing positive for SARS-CoV-2, influenza, or other respiratory viruses in both hospitalized and non-hospitalized ED patients. |
| Personalized Prenatal Care with Remote Patient Monitoring and Digital Health Interface to Detect Early Signs of Adverse Events in Pregnancy (BABYSCRIPTS) | Dr. Andrew Meltzer | This is phase one of a multi-phase post-market study to evaluate the use of Babyscripts in routine prenatal care. Individual patient- level data analysis on mixed-effects models will be performed for major outcome measures (pre-term birth, gestational diabetes and preeclampsia to determine whether usage of the Babyscripts app affects pregnancy outcomes. | |
| Clinical Evaluation of the i-STAT hs-Tnl Test to Aid in the Diagnosis of Myocardial Infraction (MI) | Dr. Andrew Meltzer | Ryan Heidish | The purpose of this study is to collect and test blood samples from individuals suspected of having a heart attack. The samples will be used to evaluate an investigational device, the i-STAT hs-Tnl cartridge, using United States Food and Drug administration (FDA) cleared i-STAT system. The results from the i-STAT hs-Tnl test will be compared to information in your medical record to see if the same diagnosis would be made using the i-STAT hs-Tnl tests results. |
| Clinical Performance of the Panther Fusion® SARS-CoV-2/Flu A/B/RSV Assay in Nasal Swab Specimens From Symptomatic Subjects in an Enriched Population | Dr. Andrew Meltzer | Aditya Loganathan | The objective of this study is to establish the positive percent agreement of the PF SARS/Flu/RSV assay for all non-SARS-CoV-2 analytes in ANS specimens collected by healthcare professionals (HCP-collected) or by the patients under supervision of a healthcare professional (patient-collected) in VTM/UTM or RespDirect/eSTM from an enriched population of symptomatic individuals who reported symptoms of respiratory infection consistent with influenza or RSV and who recently tested positive for influenza or RSV |
| RADIATE: Rapid Diagnosis of Viral Acute Respiratory Infection to Decrease Unnecessary Antibiotic Utilization in the Emergency Department | Dr. Christopher Payette and Dr. Andrew Meltzer | Ryan Heidish | Study investigating the effectiveness of a rapid diagnostic approach in reducing unnecessary antibiotic use in the emergency department (ED) for patients presenting with acute respiratory illness (ARI) due to a virus. The intervention involves the implementation of a rapid point-of-care multiplex polymerase chain reaction (PCR) test to promptly identify the viral cause of the infection. |
| A multicenter randomized controlled trial to establish the impact of MeMed BV® on management of patients with suspected Lower Respiratory Tract Infections (LRTI) in the Emergency Department (ED) and Urgent Care Center (UCC) - (“BV: JUPITER” TRIAL) | Dr. Andrew Meltzer | Soroush Shahamatdar | The study aims to demonstrate MeMed BV® added value on top of standard of care in lowering unwarranted antibiotic prescribing in patients with LRTI in the ED/UCC. Additionally the study is looking to demonstrate that the use of MeMed BV in guided decision making leads to similar clinical outcomes for patients with LRTI compared to standard of care. Finally this study aims to evaluate the effect of MeMed BVs guided decision making on total number of antibiotic days, hospitalization rate, referral to ED, and adverse events due to antibiotic treatment compared to standard of care. |