Publications

2023

Walker RR, Chiappinelli KB. Protein Exaptation by Endogenous Retroviral Elements Shapes Tumor Cell Senescence and Downstream Immune Signaling. Cancer Res. 2023 Aug 15;83(16):2640-2642. doi: 10.1158/0008-5472.CAN-23-1862. PMID: 37549230.

Kanholm T, Rentia U, Hadley M, Karlow JA, Cox OL, Diab N, Bendall ML, Dawson T, McDonald JI, Xie W, Crandall KA, Burns KH, Baylin SB, Easwaran H, Chiappinelli KB. Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci. Cancer Res. 2023 Aug 1;83(15):2584-2599. doi: 10.1158/0008-5472.CAN-22-3485. PMID: 37249603.

Kim DJ, Anandh S, Null JL, Przanowski P, Bhatnagar S, Kumar P, Shelton SE, Grundy EE, Chiappinelli KB, Kamm RD, Barbie DA, Dudley AC. Priming a vascular-selective cytokine response permits CD8⁺ T-cell entry into tumors. Nat Commun. 2023 Apr 14;14(1):2122. doi: 10.1038/s41467-023-37807-z. PMID: 37055433; PMCID: PMC10101959.

Walker RR, Rentia Z, Chiappinelli KB. Epigenetically programmed resistance to chemo- and immuno-therapies. Adv Cancer Res. 2023;158:41-71. doi: 10.1016/bs.acr.2022.12.001. Epub 2023 Jan 27. PMID: 36990538.

2022

Chiappinelli KB, Baylin SB. Inhibiting DNA methylation improves antitumor immunity in ovarian cancer. J Clin Invest. 2022 Jul 15;132(14):e160186. doi: 10.1172/JCI160186. PMID: 35838045; PMCID: PMC9282922.

Gomez S, Cox OL, Walker RR 3rd, Rentia U, Hadley M, Arthofer E, Diab N, Grundy EE, Kanholm T, McDonald JI, Kobyra J, Palmer E, Noonepalle S, Villagra A, Leitenberg D, Bollard CM, Saunthararajah Y, Chiappinelli KB. Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer. J Immunother Cancer. 2022 Nov;10(11):e004974. doi: 10.1136/jitc-2022-004974. PMID: 36343976; PMCID: PMC9644370.

2021

McDonald JI, Diab N, Arthofer E, Hadley M, Kanholm T, Rentia U, Gomez S, Yu A, Grundy EE, Cox O, Topper MJ, Xing X, Strissel PL, Strick R, Wang T, Baylin SB, Chiappinelli KB. Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner. Cancer Res. 2021 Oct 15;81(20):5176-5189. doi: 10.1158/0008-5472.CAN-20-4243.

Grundy EE, Diab N, Chiappinelli KB. Transposable element regulation and expression in cancer. FEBS J. 2022 Mar;289(5):1160-1179. doi: 10.1111/febs.15722.

2020

Moufarrij S, Srivastava A, Gomez S, et al. Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer. Sci Rep. 2020;10(1):3470. Published 2020 Feb 26. doi:10.1038/s41598-020-60409-4

Banik D, Noonepalle S, Hadley M, et al. HDAC6 plays a non-canonical role in the regulation of anti-tumor immune responses, dissemination, and invasiveness of breast cancer. [published online ahead of print, 2020 Jun 30]. Cancer Res. 2020;canres.3738.2019. doi:10.1158/0008-5472.CAN-19-3738

2019

Moufarrij, Dandapani M, Arthofer E, Gomez S, Srivastava A, Lopez-Acevedo M, Villagra A, Chiappinelli KB.
Epigenetic therapy for ovarian cancer: promise and progress

Clinical Epigenetics. 2019;11(1):7; doi:10.1186/s13148-018-0602-0

Pfannstiel C, Strissel PL, Chiappinelli KB, et al.The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes. Cancer Immunol Res. 2019;7(6):923-938. doi:10.1158/2326-6066.CIR-18-0758

Gomez S, Tabernacki T, Kobyra J, Roberts P, Chiappinelli KB. Combining epigenetic and immune therapy to overcome cancer resistance. Semin Cancer Biol. 2020;65:99-113. doi:10.1016/j.semcancer.2019.12.019

2017

Siebenkäs C, Chiappinelli KB, Guzzetta AA, Sharma A, Jeschke J, Vatapalli R, Baylin SB, Ahuja N.
Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells.
PloS one. 2017; 12(6):e0179501.

Topper MJ, Vaz M, Chiappinelli KB, DeStefano Shields CE, Niknafs N, Yen RC, Wenzel A, Hicks J, Ballew M, Stone M, Tran PT, Zahnow CA, Hellmann MD, Anagnostou V, Strissel PL, Strick R, Velculescu VE, Baylin SB.
Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer.
Cell. 2017; 171(6):1284-1300.e21.

Stone ML, Chiappinelli KB, Li H, Murphy LM, Travers ME, Topper MJ, Mathios D, Lim M, Shih IM, Wang TL, Hung CF, Bhargava V, Wiehagen KR, Cowley GS, Bachman KE, Strick R, Strissel PL, Baylin SB, Zahnow CA.
Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden.
Proc Natl Acad Sci USA. 2017 Dec 4. pii: 201712514. doi: 10.1073/pnas.1712514114.

2016

Chiappinelli KB, Zahnow CA, Ahuja N, Baylin SB.
Combining Epigenetic and Immunotherapy to Combat Cancer.
Cancer research. 2016; 76(7):1683-9.

Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Slamon DJ, Wolchok JD, Pardoll DM, Beckmann MW, Zahnow CA, Merghoub T, Chan TA, Baylin SB, Strick R.
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
Cell. 2016; 164(5):1073.

2015

Strick R, Strissel PL, Baylin SB, Chiappinelli KB.
Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors.
Oncoimmunology. 2015; 5(5):e1122160.

Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC Jr, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, Brenton JD, Chiappinelli KB, Martins FC, Coukos G, Drapkin R, Edmondson R, Fotopoulou C, Gabra H, Galon J, Gourley C, Heong V, Huntsman DG, Iwanicki M, Karlan BY, Kaye A, Lengyel E, Levine DA, Lu KH, McNeish IA, Menon U, Narod SA, Nelson BH, Nephew KP, Pharoah P, Powell DJ Jr, Ramos P, Romero IL, Scott CL, Sood AK, Stronach EA, Balkwill FR.
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.
Nature reviews. Cancer. 2015; 15(11):668-79.

2014

2013

Yi JM, Guzzetta AA, Bailey VJ, Downing SR, Van Neste L, Chiappinelli KB, Keeley BP, Stark A, Herrera A, Wolfgang C, Pappou EP, Iacobuzio-Donahue CA, Goggins MG, Herman JG, Wang TH, Baylin SB, Ahuja N.
Novel methylation biomarker panel for the early detection of pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research. 2013; 19(23):6544-55.

Yin Y, Kizer NT, Thaker PH, Chiappinelli KB, Trinkaus KM, Goodfellow PJ, Ma L.
Glycogen synthase kinase 3β inhibition as a therapeutic approach in the treatment of endometrial cancer.
International journal of molecular sciences. 2013; 14(8):16617-37.

2012

Chiappinelli KB, Haynes BC, Brent MR, Goodfellow PJ.
Reduced DICER1 elicits an interferon response in endometrial cancer cells.
Molecular cancer research : MCR. 2012; 10(3):316-25.

Ioffe YJ, Chiappinelli KB, Mutch DG, Zighelboim I, Goodfellow PJ.
Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?
Gynecologic oncology. 2012; 124(2):340-6.

2010

Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang LW, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, Link DC.
Complete characterization of the microRNAome in a patient with acute myeloid leukemia.
Blood. 2010; 116(24):5316-26.

Chiappinelli KB, Rimel BJ, Massad LS, Goodfellow PJ.
Infrequent methylation of the DUSP6 phosphatase in endometrial cancer.
Gynecologic oncology. 2010; 119(1):146-50.

Saharia A, Teasley DC, Duxin JP, Dao B, Chiappinelli KB, Stewart SA.
FEN1 ensures telomere stability by facilitating replication fork re-initiation.
The Journal of biological chemistry. 2010; 285(35):27057-66.