Brindley PJ, Loukas A. (2017) Helminth infection-induced malignancy. PLOS Pathogens, Pearl 13(7): e1006393 

Dheilly NM, Bolnick D, Bordenstein S, Brindley PJ, Figueres C, Holmes EC, Martínez MJ, Phillips AJ, Poulin R, Rosario K. The Parasite Microbiome Project (PMP) to systematically investigate microbiome dynamics within and across parasite-host interactions. mSystems 2(4) e00050-17

Gouveia MJ, Pakharukova MY, Laha, T, Sripa, B, Maksimova GA, Rinaldi G, Brindley PJ, Mordvinov VA, Amaro T, Santos LL, Correia da Costa JM, Vale N. (2017) Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model. Carcinogenesis, in press DOI:

Bansal PS, Smout MJ, Wilson D, Caceres CC, Dastpeyman M, Seifert J, Brindley PJ, Loukas A, Daly NL. (2017) Development of a potent wound healing agent based on the liver fluke granulin scaffold. Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.7b00047

Gouveia MJ, Rinaldi G, Brindley PJ, Correia da Costa JM, Vale N. (2017) Praziquantel for schistosomiasis: a single drug revisited. Antimicrobial Agents & Chemotherapy 61:5 16 e02582-16

Van Tong H, Brindley PJ, Meyer CG, Velavan TP (2017) Parasite infection, carcinogenesis and human malignancy. eBioMedicine, 15, 12-23 

McNulty SN, Tort JF, Rinaldi G, Fischer PU, Rosa BA, Smircich P, Fontenla S, Choi YJ, Tyagi R, Hallsworth-Pepin K, Mann VH, Kammili L, Latham PS, Dell’Oca N, Dominguez F, Carmona C, Fischer K, Brindley PJ, Mitreva M. (2017) Genomes of Fasciola hepatica from the Americas reveal colonization with Neorickettsia endobacteria related to the agents of Potomac horse and human Sennetsu fevers. PLoS Genetics 13(1):e1006537

Wang J, Yu Y, Shen H, Qing T, Xuan J, Li Q, Wang S, Li N, Chai R, Xu B, Liu M, Brindley PJ, McManus DP, Shi L, Hu W.  (2017) Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for reproduction inSchistosoma japonicum. Nature Communications 8, 14693

Deenonpoe R, Mairiang E, Mairiang P, Pairojkul C, Chamgramol Y, Rinaldi G, Loukas A, Brindley PJ, Sripa B. (2017) Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease. Scientific Reports 7_42744

Mitta G, Gourbal B, Grunau C, Knight M, Bridger JM, Theron A (2017) Biomphalaria glabrata snails and Schistosoma mansoni: an increasingly complex puzzle. Advances in Parasitology 97, 111-145.

Vale N, Gouveia MJ, Rinaldi G, Santos, J. Santos LL, Brindley PJ, Correia da Costa JM (2017) Urogenital schistosomiasis-induced bladder cancer: the role of estradiol pathways and metabolites. Tumor Biology Mar;39(3):1010428317692247.

Suttiprapa S, Rinaldi G, Tsai IJ, Mann VH, Dubrovsky L, Yan HB, Holroyd N, Huckvale T, Durrant C, Protasio AV, Pushkarsky T, Iordanskiy S, Berriman M, Bukrinsky MI, Brindley PJ. (2016) HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni. PLoS Pathogens; 12(10):e1005931.

Saltykova IV, Petrov VA, Logacheva MD, Ivanova PG, Merzlikin NV, Sazonov AE, Ogorodova L, Brindley PJ. (2016) Biliary microbiota, gallstone disease and infection with Opisthorchis felineus. PLoS Neglected Tropical Diseases10(7):e0004809.

Knight M, Ittiprasert W, Arican-Goktas HD, Bridger JM (2016) Epigenetic modulation, stress and plasticity in susceptibility of the snail host, Biomphalaria glabrata to Schistosoma mansoni infection. International Journal for Parasitology, 46(7):389-94.

Saltykova IV, Ogorodova LM, Ivanov VV, Bogdanov AO, Gereng EA, Perina EA, Brindley PJ, Sazonov AE (2016) Carbonyl stress phenomena during chronic infection with Opisthorchis felineus. Parasitology International, in press.

Bernardo C, Cunha MC, Santos JH, da Costa JM, Brindley PJ, Lopes C, Amado F, Ferreira R, Vitorino R, Santos LL (2016) Insight into the molecular basis of Schistosoma haematobium-induced bladder cancer through urine proteomics. Tumor Biology, in press.

Brindley PJ, Costa JM, Sripa B. (2015) Why does infection with some helminths cause cancer? Trends in Cancer, in press.

Smout MJ, Sotillo J, Laha T, Papatpremsiri A, Rinaldi G, Pimenta RN, Chan LY, Johnson MS, Turnbull L, Whitchurch CB, Giacomin PR, Moran CS, Golledge J, Daly N, Sripa B, Mulvenna JP, Brindley PJ, Loukas A. (2015) Carcinogenic parasite secretes growth factor that accelerates wound healing and potentially promotes neoplasia. PLoS Pathogens 20;11(10):e1005209.

Pakharukova MY, Vavilin VA, Duzhak TG, Sripa B, Laha T, Brindley PJ, Mordvinov VA.(2015) Functional analysis of the unique cytochrome P450 of the liver fluke Opisthorchis felineus. PLoS Neglected Tropical Diseases 9(12):e0004258. 

Knight M, Elhelu O, Smith M, Haugen B, Miller A, Raghavan N, Wellman C, Cousin C, Dixon F, Mann V, Rinaldi G, Ittiprasert W, Brindley PJ. (2015) Susceptibility of snails to infection with schistosomes is influenced by temperature and expression of heat shock proteins. Epidemiology (Sunnyvale). 2015 5(2). pii: 189.

Rinaldi G, Loukas A, Brindley PJ, Irelan J, Smout MJ. (2015) Viability of developmental stages of Schistosoma mansoni quantified with xCELLigence worm real-time motility assay (xWORM)International Journal for Parasitology: Drugs and Drug Resistance 5, 141-148      

Matchimakul P, Rinaldi G, Suttiprapa S, Mann VH, Popratiloff A, Pimenta, RN, Laha T, Cochran CJ, Kaewkes S, Sripa B, Brindley PJ (2015) Apoptosis of cholangiocytes modulated by thioredoxin of carcinogenic liver fluke. International Journal of Biochemistry & Cell Biology 65, 72-80

Wang JP, Shu-Qi Wang S-Q, Liu X-F, Xu B, Chai R-Y, Zhou P, Ju C, Sun J, Brindley PJ, Hu W. (2015) Intake of erythrocytes required for reproductive development of female Schistosoma japonicum. PLoS ONE 10(5):e0126822

Jurberg AD, Brindley PJ. (2015) Gene function in schistosomes: recent advances towards a cure. Editorial. Frontiers of Genetics 6:144

Rinaldi G, Yan H, Nacif-Pimenta R, Matchimakul P Bridger JM, Mann VH, Smout MJ, Brindley PJ, Knight M. (2015) Cytometric analysis, genetic manipulation and antibiotic selection of the snail embryonic cell line Bge from Biomphalaria glabrata, the intermediate host of Schistosoma mansoni. International Journal for Parasitology, International Journal for Parasitology 48, 527-535

Deenonpoe R, Chomvarin C, Pairojkul C, Chamgramol Y, Loukas A, Brindley PJ, Sripa B. (2015) The carcinogenic liver fluke Opisthorchis viverrini is a reservoir for species of Helicobacter. Asian Pacific Journal of Cancer Prevention 16, 1751-1758

Gouveia MJ, Santos J, Brindley PJ, Rinaldi G, Lopes C, Santos LL, Vale N, Correia da Costa JM (2015) Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer. Cancer Letters, 359, 226-232

Martin M, Rosa BA, Ozersky P, Wang Q, Hallsworth-Pepin K, Zhang X, Bhonagiri-Palsikar V, Tyagi R, Choi Y-J, Gao X, McNulty S, Brindley PJ, Mitreva M. (2015) expansions to and an introduction to Nucleic Acids Research 43, D698-706

Ogorodova LM, Fedorova OS, Sripa B, Mordvinov VA, Katokhin AV, Keiser J, Odermatt P, Brindley PJ, Mayboroda OA, Velavan TP, Freidin MV, Sazonov AE, Saltykova IV, Pakharukova MY, Kovshirina V, Kaloulis K, Krylova O, Yazdanbakhsh M, and the TOPIC Consortium  (2015) Opisthorchiasis. Overlooked danger. PLoS Neglected Tropical Diseases 9(4): e0003563. doi:10.1371/journal.pntd.0003563

Papatpremsiri A, Smout MJ, Loukas A, Brindley PJ, Sripa B, Laha T. (2015) Suppression of Ov-grn-1 encoding granulin of Opisthorchis viverrini inhibits proliferation of biliary epithelial cells. Experimental Parasitology 148, 17-23

Correia da Costa JM, Vale N, Gouveia MJ, Botelho M, Sripa B, Santos LL, Santos J, Rinaldi
G, Brindley PJ (2014) Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers. Frontiers in Genetics 5:444

Knight M, Arican-Goktas HD, Ittiprasert W, Odoemelam EC, Miller AN, Bridger JM (2014) Schistosomes and snails: a molecular encounter. Frontiers in Genetics 5:230

Hoffmann KF, Brindley PJ, Berriman M. (2014) Halting harmful helminths. Science, 346,

Dell’oca N, Basika T, Corvo I, Castillo E, Brindley PJ, Rinaldi G, Tort JF. (2014) RNAi optimization in Fasciola hepatica newly excysted juveniles: long dsRNA induces more persistent silencing than siRNA. Molecular & Biochemical Parasitology 197, 28-35

Santos J, Fernandes E, Ferreira JA, Lima L, Tavares A, Parreira BS, Correia da Costa JM, Brindley PJ, Lopes C, Santos LL. (2014) P53 and cancer-associated sialylated glycans are surrogate markers of cancerization of the bladder associated with Schistosoma haematobium infection.  PLoS Neglected Tropical Diseases 8(12): e3329

Papatpremsiri A, Junpue P, Loukas A, Brindley PJ, Bethony JM, Sripa B, Laha T. (2014)
Immunization and challenge shown by hamsters infected with Opisthorchis viverrini
following exposure to gamma-irradiated metacercariae of this carcinogenic liver fluke.
Journal of Helminthology, 15, 1-9

Arican-Goktas HD, Ittiprasert W, Bridger JM, Knight M (2014) Differential spatial
repositioning of activated genes in Biomphalaria glabrata snails infected with
Schistosoma mansoni. PLoS Neglected Tropical Diseases 8(9): e3013,

Rinaldi G, Honeycutt J, Young ND, Gasser RB, Brindley PJ, Hsieh MH. (2014) New research tools for urogenital schistosomiasis. Journal of Infectious Diseases, in press.

Plieskatt JL*, Rinaldi G*, Feng Y, Peng J, Yonglitthipagon P, Easley S, Laha T, Pairojkul C, Bhudhisawasdi V, Sripa B, Brindley PJ, Mulvenna JP, Bethony JM. (2014) Distinct miRNA signatures associate with subtypes of cholangiocarcinoma from infection with the tumorigenic liver fluke Opisthorchis viverrini. Journal of Hepatology, 61, 850-858 (*Equal contribution.)

Mann VH, Suttiprapa S, Skinner DE, Brindley PJ, Rinaldi G (2014) Pseudotyped murine leukemia virus for schistosome transgenesis: approaches, methods and perspectives. Transgenic Research 23, 539-556

Zeraik AE, Galkin VE, Rinaldi, G, Garratt RC, Smout MJ, Loukas A, Mann VH, Araujo AP, DeMarco R, Brindley PJ (2014) Reversible paralysis of Schistosoma mansoni by forchlorfenuron, a phenylurea cytokinin that affects septins. International Journal for Parasitology 44, 523-531

Thanasuwan S, Piratae S, Brindley PJ, Loukas A, Kaewkes S, Laha T. (2014) Suppression ofaquaporin, a mediator of water channel control in the carcinogenic liver fluke, Opisthorchisviverrini. Parasites & Vectors 7:22

Santos J, Gouveia MJ, Vale N, de Lurdes Delgado M, Gonçalves A, Teixeira da Silva JM, Oliveira C, Xavier P, Gomes P, Santos LL, Lopes C, Barros A, Rinaldi G, Brindley PJ, Correia da Costa JM, Sousa M, Botelho MC (2014) Urinary estrogen metabolites and self-reported infertility inwomen infected with Schistosoma haematobium. PLoS One, 9(5): e96774

Plieskatt J, Rinaldi G, Brindley PJ, Jia X, Potriquet J, Bethony J, Mulvenna J. (2014) BioClojure:A functional library for the manipulation of biological sequences. Bioinformatics,

Yan H-B, Lou ZZ, Li L, Zheng Y, Brindley PJ, Luo X, Hou H, Guo A, Jia W-Z, Cai X-P. (2014)Genome-wide analysis of regulatory proteases sequences identified through bioinformatics data mining in Taenia solium. BMC Genomics 15(1):428

Skinner DE, Rinaldi G, Koziol U, Brehm K, Brindley PJ (2014) How might flukes and tapeworms maintain genome integrity without a canonical piRNA pathway? Trends in Parasitology 30 (3), 123-129

Zeraik AE, Rinaldi G, Mann VH, Popratiloff A, Araujo APU, DeMarco R, Brindley PJ (2013) Septins of platyhelminths: identification, phylogeny, expression and localization amongdevelopmental stages of Schistosoma mansoni. PLoS Neglected Tropical Diseases 7(12):e2602.

Plieskatt JL, Deenonpoe R, Mulvenna JP, Krause L, Sripa B, Bethony JM, Brindley PJ (2013) Infection with carcinogenic liver fluke Opisthorchis viverrini modifies intestinal and biliary microbiome. FASEB Journal 27, 4572-4584

Vale N, Gouveia MJ, Botelho M, Sripa B, Suttiprapa S, Rinaldi G, Gomes P, Brindley PJ, Correia da Costa JM (2013) Carcinogenic liver fluke Opisthorchis viverrini oxysterols detected by LC-MS/MS survey of soluble fraction parasite extract. Parasitology International, 62, 535-542

Botelho MC, Vale N, Gouveia MJ, Rinaldi G, Santos J, Santos LL, Gomes P, Brindley PJ, Costa JM (2013) Tumour-like phenotypes in urothelial cells after exposure to antigens from eggs of Schistosoma haematobium: An oestrogen–DNA adducts mediated pathway? International Journal for Parasitology 43, 17-26

Brindley PJ, Hotez PJ. (2013) Break out: Urogenital schistosomiasis and Schistosoma haematobium infection in the post-genomic era.  PLOS Neglected Tropical Diseases 7(3): e1961. PMC 3610632

Ittiprasert W, Miller A, Su X, Mu J, Bhusudsawang G, Ukoskit K, Knight M (2013) Identification and characterization of functional eSSR markers for genetic linkage mapping of Schistosoma mansoni juvenile resistance and susceptibility loci in Biomphalaria glabrata Int. J. Parasitol 43, 669-77

Rinaldi G, Eckert SE, Tsai IJ, Suttiprapa S, Kines KJ, Tort JF, Mann VH, Turner DJ, Berriman M, Brindley PJ (2012) Germline transgenesis and insertional mutagenesis in Schistosoma mansoni mediated by Murine Leukemia Virus.  PLoS Pathogens 8(7): e1002820. PMC 3406096

Sripa B, Brindley PJ, Mulvenna J, Laha T, Smout MJ, Mairiang E, Bethony JM, Loukas A  (2012) The tumorigenic liver fluke Opisthorchis viverrini – multiple pathways to cancer. Trends in Parasitology 28, 395-407.

Young ND, Jex AR, Li B, Liu S, Yang L, Xiong Z, Li L, Cantacessi C, Hall RS, Xu X, Chen F, Wu X, Zerlotini A, Oliveira G, Hofmann A, Zhang G, Fang X, Kang Y, Campbell BE, Loukas A, Ranganathan S, Rollinson D, Rinaldi G, Brindley PJ, Yang H, Wang Y, Wang J, Gasser RB (2012) Whole-genome sequence of Schistosoma haematobiumNature Genetics, 44(2), 221-215

Rinaldi G, Suttiprapa S, Tort JF, Folley AE, Skinner DE, Brinldey PJ (2012) An antibiotic selection marker for schistosome transgenesis. International Journal for Parasitology 42, 123-130

Skinner DE, Rinaldi G, Suttiprapa S, Mann VH, Smircich P, Cogswell AA, Williams DL, Brindley PJ (2012) Vasa–like DEAD-box RNA Helicases of Schistosoma mansoni.  PLoS Neglected Tropical Diseases, 6(6): e1686. doi:10.1371/journal.pntd.0001686

Ittiprasert W, Knight M (2012) Reversing the Resistance Phenotype of the Biomphalaria glabrata Snail Host Schistosoma mansoni Infection by Temperature Modulation. PLoS Pathogens 8(4): e1002677 (Evaluated in Faculty 1000)

Rinaldi G, Popratiloff A, Okatcha TI, Ayuk MA, Suttiprapa S, Mann VH, Loukas A, Brindley PJ. (2011) Genetic manipulation of Schistosoma haematobium, the neglected schistosome. PLoS Neglected Tropical Diseases, 5(10): e1348. PMC 3191139

Suttiprapa S*, Rinaldi G*, Brindley PJ (2011) Prototypic chromatin insulator cHS4 protects retroviral transgene from silencing in Schistosoma mansoni. Transgenic Research 21, 555–566 (* These authors contributed equally to this work)

Sripa B, Bethony JM, Sithithaworn P., Kaewkes S., Mairiang E., Loukas A., Mulvenna J., Laha T., Hotez PJ., Brindley PJ. (2011) Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos. Acta Tropica 120 Suppl 1:S158-68  PMC3010517

Mann VH*, Suttiprapa S*, Rinaldi G*, Brindley PJ (2011) Establishing transgenic schistosomes. PLoS Neglected Tropical Diseases. Laboratory Symposium 5(8): e1230 (* These authors contributed equally to this work)

Knight, M., Miller, A., Liu, Y., Puthupparampil, S., Woodle, M., Ittiprasert, W. (2011) Polyethyleneimine (PEI) mediated siRNA gene silencing in the Schistosoma mansoni snail host, Biomphalaria glabrata. PLoS Neglected Tropical Diseases 5 (7):e1212. Evaluated in Faculty of 1000

Knight, M., Ittiprasert, W., Odoemelam, E., Adema, M.A., Miller A., Raghavan, N., Bridger, J. (2011) Non-random organization of the Biomphalaria glabrata genome in interphase Bge cellsl and the spatial repositioning of activated genes in cell co-cultured with Schistosoma mansoniInternational Journal for Parasitology 41, 61-70. Evaluated in Faculty of 1000

Gilbert C, Schaak S, Pace II JK, Brindley PJ, Feschotte C. (2010) A role for host-parasite interactions in the horizontal transfer of transposons across phyla. Nature 464, 1347-1350. PMC3004128

Mann VH, Morales ME, Rinaldi G, Brindley PJ (2010) Culture for genetic manipulation of developmental stages of Schistosoma mansoni. Parasitology 137, 451-462. PMC 3042131

Smout MJ, Laha T, Mulvenna J, Sripa B, Suttiprapa S, Jones A, Brindley PJ, Loukas A. (2009) A  granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells.  PLoS Pathogens 5(10):e1000611. PMC2749447

Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium, Liu, F., Zhou, Y., Wang, ZQ., Lu, G., Zheng, H., Brindley PJ, McManus, D.P., Blair, D., Zhang, QH., Zhong, Y., Wang, S., Han, ZG., Chen, Z. (2009) The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature 460, 345-352

Hotez PJ, Brindley PJ, Bethony JM, Pearce EJ, King CH, Jacobsen J. (2008) Helminth infections: the great neglected tropical diseases. Journal of Clinical Investigation 118, 1,311-1,321. PMC2276811

Rinaldi G, Morales ME,  Alrefaei YN, Cancela M,  Castillo E,  Dalton JP,  Tort JF, Brindley PJ (2009) RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs. Molecular and Biochemical Parasitology 167, 118-126

Ittiprasert W, Nene R, Miller A, Raghavan N, Lewis F, Hodgson J, Knight M. (2009) Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails. Experimental Parasitology 123, 203-211

Rinaldi G, Morales ME, Cancela M, Castillo E, Brindley PJ, Tort JF (2008) Development of functional genomics tools in trematodes: RNA interference and luciferase reporter gene activity in Fasciola hepatica. PLoS Neglected Tropical Diseases 2(7):e260

Morales ME, Rinaldi G, Gobert GN,  Kines KJ, Tort JF, Brindley PJ (2008) RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascade. Molecular and Biochemical Parasitology, 157 , p. 160-168

Sripa B, Kaewkes S, Sithithaworn P, Mairiang E, Laha T, Smout M, Pairojkul C, Bhudhisawasdi V, Tesana S, Thinkamrop B, Bethony JM, Loukas A, Brindley PJ (2007) Liver fluke induces cholangiocarcinoma. PLoS Medicine 4(7): e201. PMC1913093

Knight, M., Miller A., Patterson, C., Rowe, C. Michaels, G., Carr, D., Richards, C., and Lewis, F. 1999. The identification of markers segregating with resistance to Schistosoma mansoni infection in the snail Biomphalaria glabrata. Proceedings of the National Academy of Sciences 96, 1510-1515.