Faculty Members

Faculty Research

Anthony-Samuel LaMantia, Ph.D.
Professor, Department of Pharmacology and Physiology, GW SMHS
Director, GW Institute for Neuroscience

Dr. LaMantia's laboratory studies genetic and molecular mechanisms of early forebrain development. We focus on signaling and transcriptional regulation of forebrain stem cell identity and the role of forebrain developmental regulatory genes in behavioral and psychiatric diseases including schizophrenia and autism.

Ross Hall 661
2300 I (Eye) St NW
Office phone: (202) 994-8462
Lab phone: (202) 994-8465
Email: lamantia@gwu.edu

Migrating interneurons in the embryonic brain: Dan Meechan/A. LaMantia's laboratory

Lynne Bernstein, Ph.D.
Professor, Department of Speech and Hearing Science, GW CCAS

Dr. Bernstein's research centers on perception, neural processing, and training of unisensory and multisensory speech stimuli in individuals with normal and with impaired hearing. She applies a wide range of methods, including behavioral, computational, and neuroimaging. Participants in experiments have included individuals with a range of hearing losses of various etiologies, including congenital profound hearing loss and acquired central auditory processing disorders. The participants with hearing loss have used a multiple modalities for communication, including lipreading, hearing aids, sign language, and/or cochlear implants. Dr. Bernstein's experience in science also includes five years at the US National Science Foundation as the Program Director for the Cognitive Neuroscience Program. That position afforded her the opportunity to gain an extensive understanding of the details and breadth of current cognitive neuroscience research. Presently, Dr. Bernstein has several research projects. One concerns developing training methods for improving lipreading; another concerns developing methods to assess and understand the underlying disorder/s in adults with normal hearing but excessive difficulty perceiving speech in background noise; a third focuses on perceptual learning of vibrotactile stimuli; and the fourth on the visual pathway's role in visual speech perception.

Rome Hall 550
801 22nd St NW
Office phone: (202) 994-7403
Email: lbernste@gwu.edu

L. Bernstein's laboratory

Vincent A. Chiappinelli, Ph.D.
The Ralph E. Loewy Professor and Chair, Department of Pharmacology & Physiology, GW SMHS

Dr. Chiappinelli's laboratory studies visual information processing in the thalamus through patch clamp electrophysiology in brain slices in parallel with morphological studies of the relationships between thalamic neurons. The major focus is on the role of nicotinic receptors and cholinergic afferents in synaptic transmission through the visual thalamus.

Ross Hall 630
2300 I (Eye) St NW
Office phone: (202) 994-3541
Email: vac@gwu.edu

A thalamic neuron fluorescently labeled after physiological recording: V. Chiappinelli's laboratory

Anne Chiaramello

Anne Chiaramello, Ph.D.
Associate Professor, Department of Anatomy and Regenerative Biology, GW SMHS

Dr. Chiaramello's laboratory studies molecular mechanisms of mitochondrial biogenesis and bioenergetics regulating neuronal differentiation and survival.

Ross Hall 425
2300 I (Eye) St NW
Office phone: (202) 994-2173
Lab phone: (202) 994-8465
Email: achiaram@gwu.edu

 

Matt Colonnese

Matt Colonnese, Ph.D.
Assistant Professor, Department of Pharmacology and Physiology, GW SMHS

Dr. Colonnese's lab asks how do we develop the ability to actively explore and perceive our sensory environment? Such perception does not result simply from brain activity driven by the external world, but by its collision with activity generated internally. The lab is determining what processes drive the developmental initiation of this internal activity at the cellular, network and metabolic levels using a host of electrophysiological and imaging techniques in vivo in rats and mice.

Ross Hall 639
2300 I (Eye) St NW
Office phone: (202) 994-2926
Email: colonnese@gwu.edu

Science Image

M. Colonnese laboratory

Joshua Corbin

Joshua Corbin, Ph.D.
Principal Investigator, Center for Neuroscience Research, Children's National Health System
Associate Professor, Departments of Pediatrics, Pharmacology and Physiology, GW SMHS

Dr. Corbin's laboratory studies the genetic and cellular processes that govern normal development of the amygdala, as well as the underlying defects in these processes that occur during developmental disorders, with a specific focus on autism and autism spectrum disorders. To accomplish these goals, we use a combination of modern tools of mouse genetics in animal models of neurodevelopmental disorders.

Children's National Health System
Center for Neuroscience Research
111 Michigan Ave NW, M7647
Voice: (202) 476-6281
Email: jcorbin@cnmcresearch.org

Corbin Migration

Migrating forebrain interneurons: J. Corbin laboratory

William D. GaillardWilliam D. Gaillard, M.D.
Professor, Departments of NeurologyPediatrics, GW SMHS
Associate Director, Center for Neuroscience Research, Children's National Health System

Dr. Gaillard's laboratory uses advanced structural and functional imaging to examine the effects of neurological disease and developmental disorders, primarily epilepsy, on brain structure and function. Our work has direct clinical implications in planning epilepsy surgery and we explore the neural underpinnings of brain plasticity.

Children's National Health System
Center for Neuroscience Research
111 Michigan Ave NW, 6th floor
Office phone: (202) 476-2120
Email: wgaillar@cnmc.org

Functional magnetic resonance imaging (fMRI) of a cognitive task: W. Gaillard's laboratory

Vittorio Gallo, Ph.D.
Wolf-Pack Chair and Director, Center for Neuroscience Research, Children's National Health System
Professor, Departments of Pediatrics, Pharmacology and Physiology, GW SMHS

Dr. Gallo's laboratory studies neural progenitor development as well as the response to injury in the immature and adult brain. The lab focuses on questions of oligodendrocyte development and myelination, as well as Neuron-glia communication in the CNS during development and after injury.

Children's National Health System
Center for Neuroscience Research
111 Michigan Ave NW, M7643
Office phone: (202) 476-4996
Lab phone: (202) 476-5922
Fax: (202) 476-4988
Email: vgallo@cnmcresearch.org

 

Andrea GropmanAndrea Gropman, M.D.
Principal Investigator, Center for Neuroscience Research, Children's National Health System
Associate Professor, Departments of NeurologyPediatrics, GW SMHS

Dr. Gropman's laboratory uses advanced neuroimaging in human subjects and animal models such as fMRI, diffusion tensor imaging, and 1H magnetic resonance imaging (MRS) to study biomarkers of neurological injury in inborn errors of metabolism including urea cycle disorders, mitochondrial disorders and phenylketonuria (PKU). Dr. Gropman is also the director of the neurogenetics program at CNMC where patients with rare disorders and undiagnosed conditions are seen.

Department phone: (202) 476-2120
Office phone: (202) 476-3511
Fax: (202) 476-5226
Email: agropman@cnmc.org

Diffusion tensor imaging (DTI) of the human brain: A. Gropman's laboratory

Kazue Hashimoto-ToriiKazue Hashimoto-Torii
Principal Investigator, Center for Neuroscience Research, Children's National Health System

The goal of Hashimoto-Torii laboratory is to understand how an adverse prenatal environment interacts with genetic predisposition, thereby increasing disease susceptibility after birth. We focus on the cerebral cortex, and tackle this fundamental question using in vivo gene transfer, generation and analysis of transgenic mice, and single-cell RNA sequencing and Copy Number Variation analysis of patient-derived iPS cells and fetal brain tissue. Our approach includes manipulation of candidate molecules and genes identified by analyses of human samples as well as in vivo in mouse models to examine their roles in the pathological development of the cerebral cortex.

Children's National Health System
Center for Neuroscience Research
111 Michigan Ave NW, M7631
Washington DC, 20010-2970
Office phone: (202) 476-4449
Email: KHashimoto-Torii@cnmcresearch.org

 

Valerie HuValerie Hu, Ph.D.
Professor, Department of Biochemistry, GW SMHS

Dr. Hu's laboratory takes a systems biology approach to studying autism spectrum disorders by integrating genomic, epigenetic, and genetic analyses of cells and brain tissues from autistic and nonautistic subjects. The overall goals are to develop a better understanding of the molecular pathology of autism which will aid in the development of better therapeutics as well as to identify molecular biomarkers for diagnostic screening.

Ross Hall 232A
2300 I (Eye) St NW
Office phone: (202) 994-8431
Email: valhu@gwu.edu

 

Henry Kaminski, Ph.D.
Chairman, Department of Neurology, GW SMHS
Professor, Departments of Neurology, Pharmacology and Physiology, GW SMHS

Dr. Kaminski is a neurologist who specializes in therapeutic development for the autoimmune, neuromuscular disorder myasthenia gravis. He has performed clinical and basic investigations related to myasthenia gravis for the last 20 years. His laboratory has pioneered development of complement based therapeutics in collaboration with industry as well as his own intellectual property. He is working closely with Linda Kusner, his colleague of many years, exploring the mechanistic links between maintenance of neoplastic cells and autoreactive cells in myasthenia gravis. He and colleagues in China are investigating IL-17 mechanisms that modulate myasthenia with an eye on inhibition of IL-17 to moderate disease severity. He is part of the executive committee of the NIH-funded study of thymectomy for treatment of myasthenia gravis and directs the supplemental study Biomarkers for Myasthenia Gravis. On the clinical research side, he has part of the Myasthenia Gravis Foundation of America Task Force which established standards for performance of clinical trials in myasthenia gravis, which have now been internationally accepted and he also was part of the committee that updated these standards this year. He is a member of the NINDS Common Data Element Committee for neuromuscular disorders and myasthenia gravis.

Medical Faculty Associates
Department of Neurology
2150 Pennsylvania Ave NW
Office phone: (202) 741-2710
Email: hkaminski@mfa.gwu.edu

H. Kaminski's laboratory

Mohamad Z. KoubeissiMohamad Z. Koubeissi, M.D.
Associate Professor, Department of Neurology
Director, Epilepsy Center, GWU-MFA

The goal of my research is to develop new interventions to treat seizures in temporal lobe epilepsy without compromising memory. Epileptogenic regions in temporal lobe epilepsy often include the hippocampus, which is crucial for memory. We have assessed the efficacy and tolerability of multiple hippocampal transections in temporal lobe epilepsy. The hypothesis behind this work is that certain intra-hippocampal connections are crucial for propagation of seizure discharges, but are not critical for memory processing. Thus, their transection will abolish seizures without interfering with memory. In paralle, we study the effects of low frequency stimulation of a white matter tract that is connected to the hippocampus in animal models of temporal lobe epilepsy. Both projects have led to a proof-of-principle trial in humans, and more extensive clinical trials are being planned.

George Washington University-MFA
2150 Pennsylvania Ave., NW; Suite 7-404
Office phone: (202) 741-2439
Fax: (202) 677-6206
Email: mkoubeissi@mfa.gwu.edu

Locations of the fornix and hippocampal electrodes and the hippocampal evoked response elicited by stimulation of the fornix

Dwight Kravitz, Ph.D.
Assistant Professor, Department of Psychology, GW CCAS

A key goal of cognitive neuroscience is to understand the relationship between neuroanatomy (i.e. connectivity and local circuitry), experience, and neural representations. I study this relationship in using many techniques with an emphasis on human fMRI and behavior. I utilize a data-driven approach paired with many conditions allowing for the data-driven quantification of the structure of neural representations. I apply this approach in a number of domains including visual object recognition, the representation of words, concepts, and scenes, mental imagery, and working memory. I also study patient populations with deficits in these processes resulting from either brain damage or disorder (e.g. autism). Ultimately, achieving convergence between data gained from studying animals, humans, and patient populations with a variety of methods is the only way to overcome the inherent limitations of any method of studying the brain of living, behaving organisms.

2125 G St NW, 206
Office phone: (202) 994-6697
Email: kravitzd@gwu.edu

D. Kravitz's laboratory

Linda L. Kusner, Ph.D.
Assistant Research Professor, Department of Pharmacology and Physiology, GW SMHS

Dr. Kusner's laboratory studies the neuromascular junction. The main focus is on myasthenia gravis, an autoimmune disease that targets the neuromascular junction, specifically the acetylcholoine receptor. Dr. Kusner has studied the influence that the complement regulators (CD59 and DAF) have on the induction of the disease. The laboratory is using the knowledge of the complement system and the strides made in the immune system development of the autoimmune producing B cells to find novel targets to ablate the disease. The laboratory utilizes the rodent models of myasthenia gravis to corroborate their targeted therapeutic. The goal of the laboratory is to develop therapeutics which will be successful in human trials of myasthenia gravis and perhaps other autoimmune diseases.

Ross Hall 723/725
2300 I (Eye) St NW
Office phone: (202) 994-6768
Email: lkusner@gwu.edu

L. Kusner's laboratory

Norman LeeNorman Lee, Ph.D.
Professor, Department of Pharmacology and Physiology, GW SMHS

Dr. Lee's laboratory focuses on the application of molecular, genomics, and computational approaches to elucidate genetic networks and pathways underlying behavioral traits, such as i.v. self-administration and tolerance of additive substances including nicotine and other drugs of abuse in inbred mouse strains. Methodologies have been developed to validate causal links between candidate genes and behavior by exploiting lentivirus-containing shRNAs delivered in vivo to specific brain regions of inbred strains.

Ross Hall 603
2300 I (Eye) St NW
Office phone: (202) 994-8855
Email: nhlee@gwu.edu

Expression microarray showing differences in gene expression after exposure to aldol:
N. Lee's/D. Perry's laboratory

Judy Liu, M.D., Ph.D.
Principal Investigator, Center for Neuroscience Research, Children's National Health System
Assistant Professor, Departments of Pediatrics, Pharmacology and Physiology, GW SMHS

Dr. Liu's laboratory works on the cellular mechanisms of neuronal migration, axon and dendrite formation. We model human neural developmental disorders caused by mutations in genes encoding cytoskeletal proteins.

Children's National Health System
Center for Neuroscience Research
111 Michigan Ave NW, M7644
Office phone: (202) 476-2383
Email: jliu@cnmcresearch.org

 

Chiara Manzini, Ph.D.Chiara Manzini, Ph.D.
Assistant Professor, Department of Pharmacology and Physiology, GW SMHS

The goal of Dr. Manzini's lab is to study the determinants of neuronal differentiation and circuit formation in the normal and diseased brain. They start from the identification of genes, which cause neurodevelopmental disorders, and are essential for normal cognition. They then use animal models (mouse and zebrafish) to recapitulate the human disease, understand pathogenesis and study the molecular mechanisms of development.

Ross Hall 650
2300 I (Eye) St NW
Email: cmanzini@gwu.edu

Gene knockdown in the zebrafish (right) recapitulates brain malformations in children (left): C. Manzini's laboratory

Paul Marvar, Ph.D.
Assistant Professor, Department of Pharmacology and Physiology, GW SMHS

The cross-disciplinary research conducted in our laboratory is focused on further understanding how psychological stress can predispose individuals to an increased risk for the development of cardiovascular diseases. We study how environmental and neurohormonal factors such as the renin angiotensin system influence the development of stress and anxiety related disorders such as post-traumatc stress disorder (PTSD) and contribute to high blood pressure (hypertension). We investigate integrative mechanisms related to the brain neurocircuitry involved in the autonomic control of blood pressure and neuroimmune pathways in hypertension.

Ross Hall 457
2300 I (Eye) St NW
Office phone: (202) 994-5584
Email: pmarvar@email.gwu.edu

Thomas MaynardThomas Maynard, Ph.D.
Associate Research Professor, Department of Pharmacology and Physiology, GW SMHS
Director, GW Institute for Neuroscience Biomarkers Discovery Core

Dr. Maynard's work focuses on the role of cell-cell signaling during neural development, and how signaling is disrupted by genetic disorders that alter chromosomal dosage. He is currently examining mouse models of 22q11 deletion syndrome, a neurodevelopmental disorder associated with psychiatric diseases, to identify how this genomic lesion alters development and function of cortical circuitry. Dr. Maynard is also the Director of the Biomarkers Discovery Core, a core facility that provides support for molecular and cell biological analysis of gene function in the developing and adult nervous system.

Ross Hall 634A
2300 I (Eye) St NW
Office phone: (202) 994-3540
Email: maynard@gwu.edu

Cortical synapses labeled for a novel mitochondrial protein: T. Maynard's laboratory

David MendelowitzDavid Mendelowitz, Ph.D.
Professor and Vice-Chairman, Department of Pharmacology and Physiology, GW SMHS

Dr. Mendelowitz's laboratory studies the central nervous system control of heart rate in health and disease. Changes in the neural control of cardiorespiratory function initiates and/or maintains cardiorespiratory diseases such as sudden infant death syndrome (SIDS) and obstructive sleep apnea (OSA). Our research focuses on establishing neurochemical links between neurons essential for respiration and neurons that control heart rate, and how risk factors, such as nicotine exposure through cigarette smoking, and intermittent hypoxia, increases the risk of SIDS in infants and arrhythmias in adults with OSA.

Ross Hall 654
2300 I (Eye) St NW
Office phone: (202) 994-3466
Fax: (202) 994-2870
Email: dmendel@gwu.edu

 

Robert Miller, Ph.D.
Senior Associate Dean for Research, GW SMHS
Vivian Gill Distinguished Research Professor, GW SMHS
Professor, Department of Anatomy and Regenerative Biology, GW SMHS

Dr. Miller has a primary interest in CNS neural development with a focus on understanding the biology of neural diseases including Multiple Sclerosis, Brain tumors and Cerebral Palsy. Dr. Miller's development research has focused on understanding the cellular and molecular mechanisms that regulate glial cell determination in the developing vertebrate CNS.

Ross Hall 709G
2300 I (Eye) St NW
Office phone: (202) 994-6988
Email: rhm3@gwu.edu

 

Sally MoodySally Moody, Ph.D.
Professor, Department of Anatomy and Regenerative Biology, GW SMHS

Dr. Moody's laboratory studies two aspects of neural developmental gene regulatory networks: (1) molecular mechanisms by which FoxD5, a forkhead/winged helix transcription factor, regulates other neural genes to control the transition from an immature to a pre-differentiation state in the neural plate; and (2) novel co-factors and down-stream targets of the Six1 transcription factor, a key regulatory gene that specifies placode-derived sensory structures of the vertebrate head. This information is being used to discover new genes involved in neural tube and craniofacial birth defects.

Ross Hall 207
2300 I (Eye) St NW
Office phone: (202) 994-2878
Email: samoody@gwu.edu

Molecularly distinct retinal neurons:
S. Moody's laboratory

Damien O'HalloranDamien O'Halloran, Ph.D.
Assistant Professor, Department of Biological Sciences, GW University

The O'Halloran lab is interested in understanding the cellular mechanisms that shape sensory behavior; we are also interested in how sodium calcium exchangers influence neuronal development. We use the model system C.elegans to probe these lines of inquiry.

Ross Hall 636
2300 I (Eye) St NW
Office phone: (202) 994-8955
Email: damienoh@gwu.edu

Nicotinic acetylcholine receptor expression in the brains of non-smokers and smokers:
D. Perry's laboratory

David PerryDavid Perry, Ph.D.
Professor, Department of Pharmacology and Physiology, GW SMHS

Dr. Perry's laboratory studies the neurobiology of nicotine addiction and nicotinic receptors, using receptor binding, immunoprecipitation, autoradiography, transmitter release and genomics. Recent studies have focused on the unique effects of nicotine on the developing brain, including exposure during pregnancy and during adolescence.

Ross Hall 618A
2300 I (Eye) St NW
Office phone: (202) 994-3544
Email: dcperry@gwu.edu

Nicotinic acetylcholine receptor expression in the brains of non-smokers and smokers:
D. Perry's laboratory

Kenna PeusnerKenna Peusner, Ph.D.
Professor, Department of Anatomy and Regenerative Biology, GW SMHS

Dr. Peussner's laboratory focuses on understanding the fundamental mechanism operating during recovery of function in vestibular nuclei neurons after peripheral vestibular lesions using the hatchling chicken model. The laboratory also focuses on understanding the cellular and molecular mechanism operating during central vestibular system development, and the possible link between reexpression of developmental mechanisms after lesions to the adults system.

Ross Hall 209
2300 I (Eye) St NW
Office phone: (202) 994-3489
Email: peusnerk@gwu.edu

 

Anastas PopratiloffAnastas Popratiloff, M.D., Ph.D.
Associate Research Professor, Department of Anatomy and Regenerative Biology
Director, Microscopy and Image Analysis, GW SMHS

Dr. Popratiloff's work focuses on neuronal and synaptic organization in normal brain structures and during adaptive plasticity after injury. In conjunction with his role as director of the Center for Microscopy and Image Analysis at GW SMHSMC, he utilizes microscopic imaging and image analysis in his work on synaptic organization and neuronal plasticity.

Ross Hall 215
2300 I (Eye) St NW
Office phone: (202) 994-2164
Email: anastas@gwu.edu

 

Lawrence A. RothblatLawrence A. Rothblat, Ph.D.
Professor, Department of Psychology, GW CCAS

Dr. Rothblat's laboratory is using genetically engineered mice to investigate the basis of cognitive impairment in neurodegenerative (Alzheimer's and Parkinson's) and neuropsychiatric (autism and schizophrenia) disorders.

2125 G St NW
Office phone: (202) 994-6809
Fax: (202) 994-1602
Email: lar@gwu.edu

 

Geralyn SchulzGeralyn Schulz, Ph.D.
Professor and Associate Dean for Research, Department of Speech and Hearing Science, GW CCAS

Dr. Schulz's laboratory focuses on kinematic analyses of speech production, speech motor learning, as well as kinematic analyses of articulatory movement pre and post therapy for Adult Neuromotor Disorders.

801 22nd St NW, 212 Phillips Hall
2115 G St NW, Monroe Hall of Government
Office phone: (202) 994-3548
Email: schulz@gwu.edu

 

Chet SherwoodChet Sherwood, Ph.D.
Associate Professor, Department of Anthropology, GW CCAS

Dr. Sherwood's laboratory is is dedicated to research on brain evolution in primates and other mammals. We investigate phylogenetic diversity in neural structure, with a particular focus on the cerebral cortex, including its behavioral correlates and genetic substrates.

2110 G St NW
Office phone: (202) 994-6346
Lab phone: (202) 994-5923
Email: sherwood@gwu.edu

Chimpanzee pyramidal neurons:
C. Sherwood's laboratory

Sarah ShomsteinSarah Shomstein, Ph.D.
Associate Professor, Department of Psychology, GW CCAS

Dr. Shomstein's laboratory focuses on elucidating the psychological and neural mechanisms underlying attentional selection. Research in the laboratory employs multiple methodologies including behavioral paradigms, eye tracking, and functional neuroimaging in normal individuals as well as in individual with attentional deficits following brain damage.

2125 G St NW, 309
Office phone: (202) 994-5957
Email: shom@gwu.edu

Distinct patterns of activity in the human visual cortex seen with fMRI: S. Shomstein's laboratory

Francys Subiaul, Ph.D.
Associate Professor, Department of Speech and Hearing Science, GW CCAS

Dr. Subiaul's laboratory focuses on the development of social learning and reasoning. Specifically, it has sought to characterize the cognitive and neural mechanisms underlying different imitation mechanisms in order to better predict socio-cognitive developmental in typically- and atypically-developing populations. Published and on-going research has showed that not only are different types of imitation learning dissociable (or independently of one another), but their functioning and development is independent of other asocial learning mechanisms like associative learning and recall.

Government Hall, 204
2115 G Street NW
Office phone: (202) 994-7208
Email: subiaul@gwu.edu

F. Subiaul's laboratory

Malathi ThothathiriMalathi Thothathiri, Ph.D.
Assistant Professor, Department of Speech and Hearing Science, GW CCAS

Dr. Thothathiri's lab studies the neural basis of language. We investigate the role of frontal cortex in syntax, sequencing and executive function using functional neuroimaging, the examination of patients with brain damage, and the development of language in children whose frontal regions are yet to mature.

Government Hall, 203
2115 G Street NW
Office phone: (202) 994-6945
Email: malathi@gwu.edu

M. Thothathiri's laboratory

Dr. ToriiMasaaki Torii, Ph.D.
Assistant Professor, Center for Neuroscience Research, Children's National Health System
Assistant Professor, Department of Pediatrics, GW SMHS

Dr. Torii's laboratory is interested in understanding how various neuronal subtypes in the cerebral cortex are assembled into functional cortical columns, and how these neurons establish specific neuronal connections during development. We are also interested in how these processes are disrupted in neurodevelopmental disorders such as autism. To address these questions, we use a combination of in vivo gene manipulation and mouse models of neurodevelopmental disorders.

Children's National Health System
Center for Neuroscience Research
111 Michigan Ave NW, M7631
Washington DC, 20010-2970
Office phone: (202) 476-4279
Email: MTorii@cnmcresearch.org

Dr. Torii's laboratory

Jason TriplettJason Triplett, Ph.D.
Principal investigator, Center for Neuroscience Research, Children's National Health System
Assistant Professor, Departments of Pediatrics, Pharmacology & Physiology, GW SMHS

Dr. Triplett's lab studies the genetic and activity-dependent cues that direct proper wiring in the brain. During development, billions of neurons need to make trillions of synapses in a precise manner to mediate proper sensory perception, behaviors and cognitive processes. To understand the cellular processes involved in precise wiring, we utilize anatomical tracing methods, electrophysiology and molecular techniques in transgenic mouse models.

Children's National Health System
Center for Neuroscience Research
111 Michigan Ave NW, M7632
Office phone: (202) 476-3985
Email: JTriplett@cnmcresearch.org

Labeled neurons from the visual cortex project to the superior colliculus and refine during the second postnatal week. J. Triplett's laboratory.

Greg Wallace, Ph.D.
Assistant Professor, Department of Speech and Hearing Sciences, GW CCAS

Dr. Wallace’s lab focuses on neuropsychological functioning and outcome in social-emotional disorders (particularly autism spectrum disorder) and how typical individual differences in social-emotional behavior affect cognition and both brain structure and function.  Dr. Wallace’s lab employs various methodologies including structural and functional magnetic resonance imaging, neuropsychological assessment, and behavioral paradigms.

Hall of Government, 211
2115 G St. NW
Office phone: (202) 994-8285
Email: gwallac1@gwu.edu

 

Among 323 typically developing youth, cortical thickness correlates negatively with autistic traits (shown in blue) and antisocial traits (in green) in largely distinct regions.

Linda WerlingLinda Werling, Ph.D.
Associate Dean for Graduate Education
Director, Institute for Biomedical Sciences, GW SMHS
Professor, Departments of Pharmacology & Physiology, Neurological Surgery, GW SMHS

Dr. Werling is Director of the Institute for Biomedical Sciences (IBS) and Associate Dean for Graduate Education. In this capacity, she leads the Ph.D. program for Biomedical Science students and serves as their Academic Advisor in the first year of Ph.D. training. Her research interests focus on regulation of neurotransmitter transporters and sigma opioid receptor function in brain.

Ross Hall 619A
2300 I (Eye) St NW
Office phone: (202) 994-2918
Fax: (202) 994-1602
Email: lwerling@gwu.edu

 

Guangying WuGuangying Wu, Ph.D.
Assistant Professor, Department of Psychology, GW CCAS

Dr. Wu's laboratory uses electrophysiological, imaging and behavioral methods to elucidate neural circuitry mechanisms underlying normal and abnormal sensory information processing and related behaviors in systems-level. Two research lines are currently conducted: one is focused on the emergence of auditory feature selectivity (such as sound phase, direction, location, etc.); the other one adopts top-down approach to study the vocalization system of the mouse brain.

2125 G St NW, 404
Office Phone: (202) 994-7681 (Psychology Department) ; (202) 994-5035 (Ross Hall)
Email: gwu2@gwu.edu

Illustration to the research figure: Mapping the receptive fields of excitatory and inhibitory synaptic inputs of auditory neurons. G. Wu's laboratory.

Xiaoyan ZhengXiaoyan Zheng, Ph.D.
Assistant Professor, Department of Anatomy and Regenerative Biology, GW SMHS

The Hedgehog (Hh) signaling pathway organizes pattern formation in a variety of embryonic tissues and functions post-embryonically in homeostatic processes. Hh pathway dysfunction thus can lead to embryonic pattern disruptions, such as holoprosencephaly and other birth defects in humans; post-embryonic dysfunction can result in failure of adult tissue regeneration as well as proliferative disorders, such as cancer

Dr. Zheng's laboratory focuses on (I) identifying target genes regulated by the Hh signal, and (II) studying the biochemical and cell biological principles governing a critical yet poorly understood step of Hh signal transduction: trafficking of Hh receptors.

Ross Hall 205
2300 I (Eye) St NW
Email: xzheng@gwu.edu

 

Irene ZohnIrene Zohn, Ph.D.
Assistant Professor, Center for Neuroscience Research, Children's National Health System
Assistant Professor, Departments of Pediatrics, Pharmacology and Physiology, GW SMHS

Dr. Zohn's laboratory is interested in understanding the pathways that regulate morphogenesis of the neural tube. As a model system we utilize several novel mutant mouse lines with disruptions in neural tube closure that have provided novel insight into the pathways that regulate neurulation.

Children's National Health System
Center for Neuroscience Research
111 Michigan Ave NW, M7645
Office phone: (202) 476-2106
Fax: (202) 476-4988
Email: izohn@cnmcresearch.org

neurodevelopmental regulatory gene, Hectd1, is expressed between somites in an early mouse embryo; I. Zohn's laboratory.